ArticleMaterials (Basel, Switzerland)2022
Biphasic Properties of PVAH (Polyvinyl Alcohol Hydrogel) Reflecting Biomechanical Behavior of the Nucleus Pulposus of the Human Intervertebral Disc.
Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- [Finite element modeling and simulation study of solid-liquid biphase fiber-reinforced lumbar intervertebral disc].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Viscoelastic Hydrogel Promotes Disc Mechanical Homeostasis Repair and Delays Intervertebral Disc Degeneration via the Yes-Associated Protein Pathway.Biomaterials research · 2025Article
- Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Development of a mechanical adaptable, moisture retention capable, injectable and adhesive organohydrogel for nucleus pulposus repairing.Regenerative biomaterials · 2025Article
- Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review.Current pain and headache reports · 2024Review
- Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review.Frontiers in cell and developmental biology · 2023Review
- New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
PVAH is a mixture of solid and fluid, but its mechanical behavior has usually been described using solid material models. The purpose of this study was to obtain material properties that can reflect the mechanical behavior of polyvinyl alcohol hydrogel (PVAH) using finite element analysis, a biphasic continuum model, and to optimize the composition ratio of PVAH to replace the nucleus pulposus (NP) of the human intervertebral disc. Six types of PVAH specimens (3, 5, 7, 10, 15, 20 wt%) were prepared, then unconfined compression experiments were performed to acquire their material properties using the Holmes-Mow biphasic model. With an increasing weight percentage of PVA in PVAH, the Young's modulus increased while the permeability parameter decreased. The Young's modulus and permeability parameter were similar to those of the NP at 15 wt% and 20 wt%. The range of motion, facet joint force, and NP pressures measured from dynamic motional analysis of the lumbar segments with the NP model also exhibited similar values to those with 15~20 wt% PVAH models. Considering the structural stability and pain of the lumbar segments, it appears that 20 wt% PVAH is most suitable for replacing the NP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.