ArticlePolymers2022
HPMC Hydrogel Formation Mechanisms Unveiled by the Evaluation of the Activation Energy.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 43 citations in OpenAlex.
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- Design and Evaluation of a Multicomponent Herbal Nanogel for Mosquito Repellency: An Integrated In Silico Experimental Approach AgainstJournal of tropical medicine · 2026Article
- Multi-enzyme active temperature-sensitive hydrogel with reactive oxygen species scavenging and antimicrobial capacity for diabetic wound repair.Burns & trauma · 2026Article
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- Characterisation and Stabilisation Mechanisms of Azelaic Acid Nanosuspensions: Insights from a Dual Stabiliser System.Pharmaceutics · 2025Article
- Application of Hydrophilic Polymers to the Preparation of Prolonged-Release Minitablets with Bromhexine Hydrochloride and Bisoprolol Fumarate.Pharmaceutics · 2024Article
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- In Situ Gelling Behavior and Biopharmaceutical Characterization of Nano-Silver-Loaded Poloxamer Matrices Designed for Nasal Drug Delivery.Gels (Basel, Switzerland) · 2024Article
- Availability and Types of Pressure Ulcer Medications at Community Pharmacies in the Accra Metropolis of Ghana.Innovations in pharmacy · 2024Article
- Essential Oils as Antimicrobial Active Substances in Wound Dressings.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aqueous solutions of hydroxypropyl methylcellulose (HPMC) show inverse thermoreversible gelation, i.e., they respond to small temperature variations exhibiting sol-gel transition during heating, and reversibly gel-sol transition during cooling. According to the pertinent literature on HPMC aqueous systems, at room temperature, the loss modulus (G") is higher than the storage modulus (G'). During the heating ramp, the viscoelastic response follows a peculiar path: initially, G" and G' smoothly decrease, then drop to a minimum and finally increase. Eventually, G' overcomes G", indicating the gel formation. A recent explanation of this behaviour considers a two-step mechanism: first, phase separation occurs, then fibrils form from a polymer-rich phase and entangle, leading to a three-dimensional network. Based on this, our research focuses on the rheological analysis of the different steps of the sol-gel transition of an HPMC aqueous solution. We perform different viscoelastic tests: thermal ramps, time sweeps, and frequency sweeps at selected characteristic temperatures. We couple classical analysis of the SAOS experiments with an innovative approach based on the evaluation of the activation energy (
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