ArticlePolymers2022
Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy.Drug delivery · 2025Pooled it
- Strategically Designed Coaxial Electrospun Nanofibers of Polylactic Acid/Glycerol Monolaurate Hydroxypropyl-Foods (Basel, Switzerland) · 2026Article
- Electrospun PVP Nanofibrous Co-Loaded with Miconazole and Lidocaine for the Treatment of Oral Candidiasis.International journal of nanomedicine · 2026Article
- Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity.Journal of functional biomaterials · 2025Article
- BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: AnCurrent research in pharmacology and drug discovery · 2025Article
- A Color-Detectable Vitamin C Controlled-Release System Fabricated Using Electrospinning.Polymers · 2024Article
- Review
- Light-Driven Energy and Charge Transfer Processes between Additives within Electrospun Nanofibres.Molecules (Basel, Switzerland) · 2023Review
- A New Year's Message 2023.Polymers · 2023Article
- Electrospun core-sheath PCL nanofibers loaded with nHA and simvastatin and their potential bone regeneration applications.Frontiers in bioengineering and biotechnology · 2023Article
- Development of Verapamil Hydrochloride-loaded Biopolymer-based Composite Electrospun Nanofibrous Mats: In vivo Evaluation of Enhanced Burn Wound Healing without Scar Formation.Drug design, development and therapy · 2023Article
- Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing.Biomolecules · 2022Review
- Review
- Review
- Electrospun Core-Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance.Biomolecules · 2022Article
- A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing.Biomolecules · 2022Review
- Electrospun Core (HPMC-Acetaminophen)-Shell (PVP-Sucralose) Nanohybrids for Rapid Drug Delivery.Gels (Basel, Switzerland) · 2022Article
- Co-Loading of Inorganic Nanoparticles and Natural Oil in the Electrospun Janus Nanofibers for a Synergetic Antibacterial Effect.Pharmaceutics · 2022Article
- Elaborate design of shell component for manipulating the sustained release behavior from core-shell nanofibres.Journal of nanobiotechnology · 2022Article
- Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release.Polymers · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic F1 fibers and coaxial F2 fibers were successfully prepared using polyvinylpyrrolidone as the main polymer matrix for drug loading and the poorly water-soluble curcumin (Cur) as a model drug. The hydrophobic poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) was designed as a blank layer to change the hydrophilicity of the fiber and restrain the drug dissolution rate. The curved linear morphology without beads of F1 fibers and the straight linear morphology with few spindles of F2 fibers were characterized using field-emission environmental scanning electron microscopy. The amorphous forms of the drug and its good compatibility with polymeric matrix were verified by X-ray diffraction and attenuated total reflectance Fourier transformed infrared spectroscopy. Surface wettability and drug dissolution data showed that the weaker hydrophilicity F2 fibers (31.42° ± 3.07°) had 24 h for Cur dissolution, which was much longer than the better hydrophilic F1 fibers (15.31° ± 2.79°) that dissolved the drug in 4 h.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.