ArticlePolymers2022
Toxicity Study and Quantitative Evaluation of Polyethylene Microplastics in ICR Mice.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Targeting Modifiable Risks: Molecular Mechanisms and Population Burden of Lifestyle Factors on Male Genitourinary Health.International journal of molecular sciences · 2025Pooled it
- Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway-mediated neuroprotection and inhibition of hippocampal neuronal apoptosis.Animal models and experimental medicine · 2026Article
- Irisin and Exercise Ameliorate the Polyethylene Microplastics-Induced Blood-Testis Barrier Disruption via PGC-1α Activation and AMPK/Nrf2/HO-1 Signaling.Journal of applied toxicology : JAT · 2026Article
- Micro-Nanoplastic Exposure and Lung Cancer Biomarkers: The Role of Extracellular Vesicle-Mediated Intercellular Communication.International journal of molecular sciences · 2026Review
- Respiratory risks of microplastics and nanoplastics: Where? What? How?Innovation (Cambridge (Mass.)) · 2026Review
- A simple and reliable method for the qualitative and quantitative analysis of nano- and microplastics in organs for controlled preclinical studies.Particle and fibre toxicology · 2026Article
- Sesamin Protects Against Polystyrene Microplastics-Induced Lung Injury via Attenuating Bcl2-Mediated Apoptosis.Antioxidants (Basel, Switzerland) · 2026Article
- MXene/Cuttlefish-Ink Nanoparticles Incorporated Dual-Purification Sponge for Solar-Driven Oily Wastewater and Microplastic Remediation.Polymers · 2026Article
- Microplastic toxicity: mechanisms, assessment methods, and future research directions.Frontiers in toxicology · 2026Review
- Polystyrene microplastic stress induces adaptive responses and functional remodeling of gastrointestinal microbiota in fattening lambs.Frontiers in microbiology · 2026Article
- Toxicity Mechanisms of Microplastic and Its Effects on Ruminant Production: A Review.Biomolecules · 2025Review
- Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics.Scientific reports · 2025Article
- Airborne micro- and nanoplastics: emerging causes of respiratory diseases.Particle and fibre toxicology · 2024Review
- Article
- Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences.Current issues in molecular biology · 2024Review
- Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice.Toxicological research · 2024Article
- Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics.American journal of industrial medicine · 2023Review
- Article
- Immunodysregulatory potentials of polyethylene or polytetrafluorethylene microplastics to mice subacutely exposed via intragastric intubation.Toxicological research · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
The production, use, and waste of plastics increased worldwide, which resulted in environmental pollution and a growing public health problem. In particular, microplastics have the potential to accumulate in humans and mammals through the food chain. However, the toxicity of microplastics is not well understood. In this study, we investigated the toxicity of 10-50 μm polyethylene microplastics following single- and 28-day repeated oral administration (three different doses of microplastics of 500, 1000, and 2000 mg/kg/day) in ICR mice. For the investigation, we administered the microplastics orally for single- and 28-day repeated. Then, the histological and clinical pathology evaluations of the rodents were performed to evaluation of the toxicity test, and Raman spectroscopy was used to directly confirm the presence of polyethylene microplastics. In the single oral dose toxicity experiments, there were no changes in body weight and necropsy of the microplastics-treated group compared with that of controls. However, a histopathological evaluation revealed that inflammation from foreign bodies was evident in the lung tissue from the 28-day repeated oral dose toxicity group. Moreover, polyethylene microplastics were detected in the lung, stomach, duodenum, ileum, and serum by Raman spectroscopy. Our results corroborated the findings of lung inflammation after repeated oral administration of polyethylene microplastics. This study provides evidence of microplastic-induced toxicity following repeated exposure to mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.