Evidence map›Paper›PMID 35160340›Full record

ArticleJournal of clinical medicine2022

Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease.

Peter Lemmer, Paul Manka, Jan Best, Alisan Kahraman, Julia Kälsch, Ramiro Vilchez-Vargas, Alexander Link, Hsin Chiang, Guido Gerken, Ali Canbay and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. MetALD: Clinical aspects, pathophysiology and treatment.JHEP reports : innovation in hepatology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Silibinin Schiff Base Derivatives Counteract CClDrug design, development and therapy · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Peter LemmerDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.
Paul MankaDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.
Jan BestDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.
Alisan KahramanDepartment of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany.
Julia KälschDepartment of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany.
Ramiro Vilchez-VargasDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
Alexander LinkDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0002-9514-4562
Hsin ChiangDepartment of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-8997-8923
Guido GerkenDepartment of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany.
Ali CanbayDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.ORCID 0000-0001-6069-7899
Lars P BechmannDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.ORCID 0000-0003-3487-9810
Svenja SydorDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.ORCID 0000-0002-1349-8309
Universitätsklinikum Knappschaftskrankenhaus Bochum · DEUniversity of Duisburg-Essen · DEOtto-von-Guericke-Universität Magdeburg · DE

Funding

Wilhelm Laupitz Foundation n/a
6 · The paper itself

Abstract

Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have emerged as leading causes of chronic liver diseases worldwide. ALD and NAFLD share several pathophysiological patterns as well as histological features, while clinically, they are distinguished by the amount of alcohol consumed daily. However, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Here, we investigated the effects of moderate alcohol consumption on liver injury, lipid metabolism, and gut microbiota in 30 NAFLD-patients. We anonymously assessed drinking habits, applying the AUDIT- and CAGE-questionnaires and compared subgroups of abstainers vs. low to harmful alcohol consumers (AUDIT) and Cage 0-1 vs. Cage 2-4. Patients who did not drink any alcohol had lower levels of γGT, ALT, triglycerides, and total cholesterol. While the abundance of

Indexed as

lipid metabolismliver enzymesmicrobiotamoderate alcohol consumptionNASH

Identifiers

PMID35160340
PMCPMC8836912
OpenAlexW4210988307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.