Evidence map›Paper›PMID 35160334›Full record

ArticleJournal of clinical medicine2022

Characteristics and Outcomes of Bloodstream Infections in a Tertiary-Care Pediatric Hematology-Oncology Unit: A 10-Year Study.

Davide Mattei, Valentina Baretta, Annarita Mazzariol, Laura Maccacaro, Rita Balter, Ada Zaccaron, Elisa Bonetti, Matteo Chinello, Virginia Vitale, Giulia Caddeo and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07590648 (Phase IV, Randomized, Open Label, Parallel Groups Clinical Trial for Evaluating the Early Stop of Antibiotic Treatment in High-risk Febrile Neutropenic Oncohaematological Paediatric Patients), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07590648 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Phase IV, Randomized, Open Label, Parallel Groups Clinical Trial for Evaluating the Early Stop of Antibiotic Treatment in High-risk Febrile Neutropenic Oncohaematological Paediatric Patients (e-STOP 2)

TypeinterventionalSponsorHospital Universitari Vall d'Hebron Research InstituteRan2026 to 2028Enrolled136ConditionsFebrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid TumorsArmsEarly Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Clinical Analysis ofPathogens (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Infections withJournal of clinical medicine · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Davide MatteiPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Valentina BarettaPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Annarita MazzariolMicrobiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy.ORCID 0000-0003-2729-1007
Laura MaccacaroMicrobiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy.
Rita BalterPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Ada ZaccaronPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Elisa BonettiPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Matteo ChinelloPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Virginia VitalePaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Giulia CaddeoPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Maria Pia EspostoPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Vincenza PezzellaPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Davide GibelliniMicrobiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy.
Gloria TridelloPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.
Simone CesaroPaediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.ORCID 0000-0002-8698-9547
Azienda Ospedaliera Universitaria Integrata Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bloodstream infections (BSIs) after chemotherapy or hematopoietic stem cell transplantation (HSCT) are a leading cause of morbidity and mortality. Data on 154 BSIs that occurred in 111 onco-hematological patients (57 hematological malignancies, 28 solid tumors, and 26 non-malignant hematological diseases) were retrospectively collected and analyzed. Monomicrobial Gram-positive (GP), Gram-negative (GN), and fungal BSIs accounted for 50% (77/154), 38.3% (59/144), and 3.2% (5/154) of all episodes. Polymicrobial infections were 7.8% (12/154), while mixed bacterial-fungal infections were 0.6% (1/154). The most frequent GN isolates were

Indexed as

bacteremiabloodstream infectionempirical antibiotic therapyGram-negativeGram-positivemultidrug resistance organismneutropenianeutropenic fever

Identifiers

PMID35160334
PMCPMC8836920
OpenAlexW4211193263

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.