Evidence map›Paper›PMID 35160245›Full record

ReviewJournal of clinical medicine2022

Effects of Supervised Exercise on the Development of Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.

Marianna Danielli, Clare Gillies, Roisin Clare Thomas, Sarah Emily Melford, Philip Newton Baker, Thomas Yates, Kamlesh Khunti, Bee Kang Tan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Observational
  6. Review
  7. Pathophysiology of Maternal Obesity and Hypertension in Pregnancy.Journal of cardiovascular development and disease · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marianna DanielliDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0002-7848-5189
Clare GilliesDiabetes Research Centre, Leicester General Hospital, Leicester LE5 4PW, UK.ORCID 0000-0002-8417-9700
Roisin Clare ThomasDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.
Sarah Emily MelfordDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.
Philip Newton BakerDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.
Thomas YatesDiabetes Research Centre, Leicester General Hospital, Leicester LE5 4PW, UK.
Kamlesh KhuntiDiabetes Research Centre, Leicester General Hospital, Leicester LE5 4PW, UK.
Bee Kang TanDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0001-5836-0613
University of Leicester · GBLeicester General Hospital · GB

Funding

Medical Research Council MR/R020981/2
6 · The paper itself

Abstract

Hypertensive disorders of pregnancy (HDP) are the most common medical complication in pregnancy, affecting approximately 10-15% of pregnancies worldwide. HDP are a major cause of maternal and perinatal morbidity and mortality, and each year, worldwide, around 70,000 mothers and 500,000 babies die because of HDP. Up-to-date high-quality systematic reviews quantifying the role of exercise and the risks of developing HDP are currently lacking. Physical exercise is considered to be safe and beneficial to pregnant women. Supervised exercise has been shown to be safe and to be more beneficial than unsupervised exercise in the general population, as well as during pregnancy in women with obesity and diabetes. Therefore, we undertook a systematic review and meta-analysis to investigate the effects of women performing supervised exercise during pregnancy compared to a control group (standard antenatal care or unsupervised exercise) on the development of HDP. We searched Medline, Embase, CINHAL, and the Cochrane Library, which were searched from inception to December 2021. We included only randomized controlled trials (RCTs) investigating the development of HDP compared to a control group (standard antenatal care or unsupervised exercise) in pregnant women performing supervised exercise. Two independent reviewers selected eligible trials for meta-analysis. Data collection and analyses were performed by two independent reviewers. The PROSPERO registration number is CRD42020176814. Of 6332 articles retrieved, 16 RCTs met the eligibility criteria, comparing a total of 5939 pregnant women (2904 pregnant women in the intervention group and 3035 controls). The risk for pregnant women to develop HDP was significantly reduced in the intervention compared to the control groups, with an estimated pooled cumulative incidence of developing HDP of 3% in the intervention groups (95% CI: 3 to 4) and of 5% in the control groups (95% CI: 5 to 6), and a pooled odds ratio (OR) comparing intervention to control of 0.54 (95% CI:0.40 to 0.72,

Indexed as

exercisegestational hypertensionmeta-analysisphysical activitypre-eclampsiasystematic review

Identifiers

PMID35160245
PMCPMC8836524
OpenAlexW4210535940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.