Evidence map›Paper›PMID 35160204›Full record

ArticleJournal of clinical medicine2022

Liraglutide + PYY

Valentin Metzner, Gloria Herzog, Tobias Heckel, Thorsten Bischler, Julia Hasinger, Christoph Otto, Martin Fassnacht, Andreas Geier, Florian Seyfried, Ulrich Dischinger

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Valentin MetznerDivision of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-8633-6220
Gloria HerzogInstitute of Pathology, University of Würzburg, 97080 Würzburg, Germany.
Tobias HeckelCore Unit Systems Medicine, University of Würzburg, 97080 Würzburg, Germany.
Thorsten BischlerCore Unit Systems Medicine, University of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0001-9288-9481
Julia HasingerDivision of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Christoph OttoDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080 Würzburg, Germany.
Martin FassnachtDivision of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0001-6170-6398
Andreas GeierDivision of Hepatology, Department of Internal Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Florian SeyfriedDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-5915-8692
Ulrich DischingerDivision of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DE

Funding

IZKF Würzburg Z-2/71 and project Z-6
6 · The paper itself

Abstract

backgroundTreatment options for NAFLD are still limited. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB), has been shown to improve metabolic and histologic markers of NAFLD. Glucagon-like-peptide-1 (GLP-1) analogues lead to improvements in phase 2 clinical trials. We directly compared the effects of RYGB with a treatment using liraglutide and/or peptide tyrosine tyrosine 3-36 (PYY

methodsObese male Wistar rats (high-fat diet (HFD)-induced) were randomized into the following treatment groups: RYGB, sham-operation (sham), liraglutide (0.4 mg/kg/day), PYY

resultsRYGB and liraglutide+PYY

conclusionsThe combination therapy of liraglutide+PYY

Indexed as

gastric bypassGLP-1liraglutideNAFLDNASHobesitypeptide tyrosine tyrosine 3-36 (PYY3-36)peptide tyrosine tyrosine (PYY)RYGB

Identifiers

PMID35160204
PMCPMC8836549
OpenAlexW4210728675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.