Evidence map›Paper›PMID 35160112›Full record

ArticleJournal of clinical medicine2022

Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis.

Marta Rojas-Giménez, Clementina López-Medina, María Lourdes Ladehesa-Pineda, María Ángeles Puche-Larrubia, Ignacio Gómez-García, Jerusalem Calvo-Gutiérrez, Pedro Seguí-Azpilcueta, María Del Carmen Ábalos-Aguilera, Desirée Ruíz-Vilchez, Alejandro Escudero-Contreras and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Marta Rojas-GiménezRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.ORCID 0000-0001-8290-3542
Clementina López-MedinaRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.ORCID 0000-0002-2309-5837
María Lourdes Ladehesa-PinedaRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.
María Ángeles Puche-LarrubiaRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.
Ignacio Gómez-GarcíaRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.ORCID 0000-0002-4607-5644
Jerusalem Calvo-GutiérrezRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.
Pedro Seguí-AzpilcuetaRadiology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain.
María Del Carmen Ábalos-AguileraRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.
Desirée Ruíz-VilchezRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.ORCID 0000-0003-4197-4939
Alejandro Escudero-ContrerasRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.ORCID 0000-0001-5891-5527
Eduardo Collantes-EstévezRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, Spain.
Instituto Maimónides de Investigación Biomédica de Córdoba · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).

methodsCross-sectional study including 347 participants (148 RA, 159 SpA, and 40 controls). We measured the carotid intima media thickness (cIMT) and detection of atheromatous plaques using carotid ultrasound. We recorded disease activity (DAS28-CRP/ASDAS-CRP) and traditional cardiovascular risk factors. We performed descriptive, bivariate, and linear multivariate analyses (dependent variable: cIMT) to evaluate the influence of diagnosis on cIMT in all patients. Two additional multivariate analyses were performed by stratifying patients according to their inflammatory activity.

resultscIMT correlated with the mean CRP during the previous 5 years in RA, but not with CRP at the cut-off date. We did not find such differences in patients with SpA. The first multivariate model revealed that increased cIMT was more common in patients with RA than in those with SpA (β coefficient, 0.045; 95% confidence interval (95% CI), 0.0002-0.09;

conclusionsSubclinical atherosclerosis measured by carotid ultrasound in patients with RA and SpA is comparable when the disease is well controlled. However, when patients have moderate-high disease activity, cIMT is greater in patients with RA than in those with SpA after adjusting for age, sex, disease course, and cardiovascular risk factors. Our results point to greater involvement of disease activity in subclinical atherosclerosis in patients with RA than in those with SpA.

Indexed as

cardiovascular riskinflammatory activityrheumatoid arthritisspondyloarthritissubclinical atherosclerosis

Identifiers

PMID35160112
PMCPMC8836873
OpenAlexW4210464050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.