Evidence map›Paper›PMID 35160078›Full record

ArticleJournal of clinical medicine2022

Serum Levels of Acylcarnitines and Amino Acids Are Associated with Liberation from Organ Support in Patients with Septic Shock.

Theodore S Jennaro, Elizabeth M Viglianti, Nicholas E Ingraham, Alan E Jones, Kathleen A Stringer, Michael A Puskarich

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Sepsis and the immunometabolic inflammatory response.npj metabolic health and disease · 2026
    Review
  4. Metabolomics in neonatal sepsis: A critical appraisal of current evidence.Computational and structural biotechnology journal · 2025
    Review
  5. Application of Metabolomics across the Spectrum of Pulmonary and Critical Care Medicine.American journal of respiratory cell and molecular biology · 2024
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Theodore S JennaroDepartment of Clinical Pharmacy and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Elizabeth M VigliantiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7439-6322
Nicholas E IngrahamDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0292-0594
Alan E JonesDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Kathleen A StringerDepartment of Clinical Pharmacy and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Michael A PuskarichDepartment of Emergency Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55415, USA.
University of Michigan · USUniversity of Minnesota · USJackson Memorial Hospital · US

Funding

L-carnitine Treatment for Vasopressor Dependent Septic ShockR01GM103799 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI JONES, ALAN E · 2012 to 2016
$3.1M
Translational Metabolomics in Critical CareR35GM136312 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KATHLEEN A STRINGER · 2020 to 2026
$2.8M
L-Carnitine Pharmacometabolomics in Sepsis (CaPS)R01GM111400 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STRINGER, KATHLEEN A · 2016 to 2019
$1.2M
Improving Risk-Stratification in Patients with Prolonged ICU StaysK23HL157364 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VIGLIANTI, ELIZABETH MARIE · 2021 to 2025
$913k
NHLBI NIH HHS K23 HL157364NIGMS NIH HHS R01GM103799NIGMS NIH HHS R01 GM111400NIGMS NIH HHS R01GM111400NIGMS NIH HHS R35 GM136312
6 · The paper itself

Abstract

Sepsis-induced metabolic dysfunction is associated with mortality, but the signatures that differentiate variable clinical outcomes among survivors are unknown. Our aim was to determine the relationship between host metabolism and chronic critical illness (CCI) in patients with septic shock. We analyzed metabolomics data from mechanically ventilated patients with vasopressor-dependent septic shock from the placebo arm of a recently completed clinical trial. Baseline serum metabolites were measured by liquid chromatography-mass spectrometry and

Indexed as

acetylcarnitineacylcarnitinesliquid chromatography-mass spectrometrymetabolomicsnuclear magnetic resonance spectroscopyorgan failuresepsis

Identifiers

PMID35160078
PMCPMC8836990
OpenAlexW4210463812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.