ArticleJournal of clinical medicine2022
Normal Anti-Thyroid Peroxidase Antibody (TPO-Ab) Titers and Active Arterial Wall Thickening among Euthyroid Individuals: A Prospective Study.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts.European journal of endocrinology · 2025Pooled it
- Age-dependent association of thyroid peroxidase antibodies with incident cardiovascular disease events: Insights from a longitudinal cohort study.Journal of translational autoimmunity · 2026Article
- Associations of Multimarkers of Metabolic Malnutrition and Inflammation With All-Cause Mortality and Their Interplay With Thyroid Function.Endocrinology, diabetes & metabolism · 2026Article
- Thyroid peroxidase antibodies and coronary artery calcification: results from the ELSA-Brasil cohort study.Journal of endocrinological investigation · 2026Article
- Sex differences in retinal neurovascular changes in type 1 diabetes without retinopathy.International journal of ophthalmology · 2026Article
- Predictors of atherosclerosis and dyslipidaemia among patients with thyroid disease: a cross-sectional analysis.Frontiers in endocrinology · 2026Observational
- Thyroid peroxidase antibodies were associated with prevalent carotid intima-media thickness in middle-age and older adults: the ELSA-Brasil cohort.Journal of endocrinological investigation · 2025Article
- Hormonal correlation with abnormal thyroid function and their auxiliary diagnostic value in breast cancer.American journal of translational research · 2025Article
- Association between atherosclerosis and height loss among older individuals.Scientific reports · 2024Article
- Deciphering thyroid function and CIMT: a Mendelian randomization study of the U-shaped influence mediated by apolipoproteins.Frontiers in endocrinology · 2024Article
- Association between anti-thyroid peroxidase antibody and thyroid stimulating hormone: a cross-sectional study.Scientific reports · 2023Article
- Height and Active Arterial Wall Thickening in Relation to Thyroid Cysts Status among Elderly Japanese: A Prospective Study.Biology · 2022Article
- Comment on "Does body height affect vascular function?"Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Association between anti-thyroid peroxidase antibody and insufficient sleep in euthyroid population.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Among euthyroid individuals, having an anti-thyroid peroxidase antibody (TPO-Ab) titer in the normal range (negative) is positively associated with atherosclerosis as evaluated based on carotid intima-media thickness (CIMT). Atherosclerosis is an established risk factor for cardiovascular disease, but no significant association between yearly progression in CIMT and cardiovascular disease has been reported. Therefore, clarifying the association between having a TPO-Ab titer in the normal range and yearly progression in CIMT (i.e., active arterial wall thickening) among euthyroid individuals could help inform strategies for preventing cardiovascular disease. We conducted a prospective study of 1069 Japanese subjects with free triiodothyronine and free thyroxine levels within the normal range. Having a TPO-Ab titer in the normal range was significantly positively associated with baseline atherosclerosis and significantly inversely associated with active arterial wall thickening. After adjusting for known confounding factors, the adjusted odds ratio (OR) and 95% confidence interval (CI) of log (TPO-Ab titer) for baseline atherosclerosis and active arterial wall thickening was 2.16 (1.07, 4.35) and 0.59 (0.37, 0.93), respectively. Since progression in CIMT is a process of aggressive endothelial repair, deficient endothelial repair inhibits active arterial wall thickening. Therefore, high-normal TPO-Ab titers might induce a deficiency in endothelial repair.
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