Evidence map›Paper›PMID 35159964›Full record

ReviewJournal of clinical medicine2022

Antithrombotic Strategies in Patients with Atrial Fibrillation and Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention.

Leonardo De Luca, Raffaella Mistrulli, Francesco Antonio Veneziano, Francesco Grigioni, Massimo Volpe, Francesco Musumeci, Domenico Gabrielli

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Coronary Artery Disease in CKD-G5D Patients: An Update.Reviews in cardiovascular medicine · 2023
    Review
  5. ANMCO-SIMEU consensus document: appropriate management of atrial fibrillation in the emergency department.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Leonardo De LucaDepartment of Cardiosciences, A.O. San Camillo-Forlanini, 13449 Roma, Italy.ORCID 0000-0002-8552-1272
Raffaella MistrulliCardiology Department, Sapienza University of Rome, Sant'Andrea Hospital, 00185 Roma, Italy.
Francesco Antonio VenezianoUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, 00128 Roma, Italy.ORCID 0000-0003-3173-2901
Francesco GrigioniUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, 00128 Roma, Italy.
Massimo VolpeCardiology Department, Sapienza University of Rome, Sant'Andrea Hospital, 00185 Roma, Italy.
Francesco MusumeciDepartment of Cardiosciences, A.O. San Camillo-Forlanini, 13449 Roma, Italy.
Domenico GabrielliDepartment of Cardiosciences, A.O. San Camillo-Forlanini, 13449 Roma, Italy.
IRCCS San Camillo Hospital · ITSapienza University of Rome · ITUniversità Campus Bio-Medico · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with atrial fibrillation (AF) are at increased risk for coronary artery disease (CAD). After percutaneous coronary intervention (PCI), the antithrombotic therapy consists of a combination of anticoagulant and antiplatelet agents to reduce the ischemic and thromboembolic risk, at the cost of increased bleeding events. In the past few years, several randomized clinical trials involving over 12,000 patients have been conducted to compare the safety of vitamin K antagonist (VKA) and direct-acting oral anticoagulants (DOACs) in association with a single- or double-antiplatelet agent, in the so-called dual- (DAT) or triple-antithrombotic therapy (TAT). These studies and several meta-analyses showed a consistent benefit for reducing bleeding events of DAT over TAT and of DOAC over VKA, without concerns about ischemic endpoints, except for a trend for increased stent thrombosis risk. The present paper examines current international guidelines' recommendations and reviews clinical trials, meta-analyses, and observational studies conducted on AF patients treated with DAT or TAT after PCI for acute coronary syndromes.

Indexed as

acute coronary syndromeatrial fibrillationdual antithrombotic therapytriple antithrombotic therapy

Identifiers

PMID35159964
PMCPMC8836736
OpenAlexW4205833576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.