Evidence map›Paper›PMID 35159947›Full record

ArticleJournal of clinical medicine2022

Prognostic Impact of CD36 Immunohistochemical Expression in Patients with Muscle-Invasive Bladder Cancer Treated with Cystectomy and Adjuvant Chemotherapy.

Juan Carlos Pardo, Tamara Sanhueza, Vicenç Ruiz de Porras, Olatz Etxaniz, Helena Rodriguez, Anna Martinez-Cardús, Enrique Grande, Daniel Castellano, Miquel A Climent, Tania Lobato and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Discovery andFrontiers in immunology · 2025
    Article
  5. Article
  6. Article
  7. Role of CD36 in cancer progression, stemness, and targeting.Frontiers in cell and developmental biology · 2022
    Review
  8. Article
  9. The role of CD36 in renal and bladder cancer.Discoveries (Craiova, Romania)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Juan Carlos PardoMedical Oncology Department, Catalan Institute of Oncology, Ctra. Can Ruti- Camí de les Escoles s/n, 08916 Badalona, Spain.
Tamara SanhuezaPathology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Vicenç Ruiz de PorrasCatalan Institute of Oncology, Badalona Applied Research Group in Oncology (B·ARGO), 08916 Badalona, Spain.ORCID 0000-0002-4352-1784
Olatz EtxanizMedical Oncology Department, Catalan Institute of Oncology, Ctra. Can Ruti- Camí de les Escoles s/n, 08916 Badalona, Spain.ORCID 0000-0002-8856-5596
Helena RodriguezGermans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain.
Anna Martinez-CardúsCatalan Institute of Oncology, Badalona Applied Research Group in Oncology (B·ARGO), 08916 Badalona, Spain.
Enrique GrandeMedical Oncology Department, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-0134-4732
Daniel CastellanoMedical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Miquel A ClimentMedical Oncology Department, Instituto Valenciano de Oncologia, 46009 Valencia, Spain.
Tania LobatoCatalan Institute of Oncology, Badalona Applied Research Group in Oncology (B·ARGO), 08916 Badalona, Spain.
Lidia EstudilloGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), CIBERONC, 28029 Madrid, Spain.ORCID 0000-0003-3891-3713
Mireia JordàGermans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain.
Cristina CarratoPathology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Albert FontMedical Oncology Department, Catalan Institute of Oncology, Ctra. Can Ruti- Camí de les Escoles s/n, 08916 Badalona, Spain.
Institut Català d'Oncologia · ESHospital Universitari Germans Trias i Pujol · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESFundación Instituto Valenciano de Oncología · ESHospital Universitario 12 De Octubre · ESMD Anderson Cancer Center Madrid · ESSpanish National Cancer Research Centre · ES

Funding

Asociación Española Contra el Cáncer Grant Grupos coordinados estables de investigación 2014
6 · The paper itself

Abstract

Neoadjuvant chemotherapy followed by a cystectomy is the standard treatment in muscle-invasive bladder cancer (MIBC). However, the role of chemotherapy in the adjuvant setting remains controversial, and therefore new prognostic and predictive biomarkers are needed to improve the selection of MIBC patients. While lipid metabolism has been related to several biological processes in many tumours, including bladder cancer, no metabolic biomarkers have been identified as prognostic in routine clinical practice. In this multicentre, retrospective study of 198 patients treated with cystectomy followed by platinum-based adjuvant chemotherapy, we analysed the immunohistochemical expression of CD36 and correlated our findings with clinicopathological characteristics and survival. CD36 immunostaining was positive in 30 patients (15%) and associated with more advanced pathologic stages (pT3b-T4;

Indexed as

adjuvant chemotherapybladder cancerCD36fatty acidlipid metabolismMIBCprognostic biomarker

Identifiers

PMID35159947
PMCPMC8836680
OpenAlexW4206686255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.