Evidence map›Paper›PMID 35159313›Full record

ArticleCells2022

Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline.

Prasant Kumar Jena, Tahereh Setayesh, Lili Sheng, Jacopo Di Lucente, Lee Way Jin, Yu-Jui Yvonne Wan

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Emerging Roles of Bile Acids in Neuroinflammation.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Brain sciences · 2023
    Article
  12. Review
  13. Review
  14. Review
  15. Symbiotic Supplementation (Cell transplantation
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Prasant Kumar JenaDepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-6729-5881
Tahereh SetayeshDepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Lili ShengDepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Jacopo Di LucenteDepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Lee Way JinDepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Yu-Jui Yvonne WanDepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-2243-7759
University of California Davis Medical Center · USCedars-Sinai Medical Center · US

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
NIA NIH HHS P30 AG072972
6 · The paper itself

Abstract

It has been shown that the Western diet (WD) induces systemic inflammation and cognitive decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced hepatic inflammation. The current study examines whether shaping the gut microbes by

Indexed as

Cognitive DysfunctionEncephalitisGastrointestinal MicrobiomeAnimalsAnti-Bacterial AgentsBifidobacteriumCholestyramine ResinDiet, WesternInflammationMiceAnti-Bacterial AgentsCholestyramine ResinBifidobacterium infantisbile acid receptorbrain inflammationgut microbiotametabolomicsneuroplasticity

Identifiers

PMID35159313
PMCPMC8834507
OpenAlexW4210276794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.