Evidence map›Paper›PMID 35159277›Full record

ReviewCells2022

The Role of Ionizing Radiation for Diagnosis and Treatment against COVID-19: Evidence and Considerations.

Marina Chalkia, Nikolaos-Achilleas Arkoudis, Emmanouil Maragkoudakis, Stamatis Rallis, Ioanna Tremi, Alexandros G Georgakilas, Vassilis Kouloulias, Efstathios Efstathopoulos, Kalliopi Platoni

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marina Chalkia2nd Department of Radiology, Medical Physics Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-7796-6001
Nikolaos-Achilleas Arkoudis2nd Department of Radiology, Diagnostic Radiology Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-0783-5700
Emmanouil Maragkoudakis2nd Department of Radiology, Radiation Oncology Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0003-2647-3677
Stamatis Rallis2nd Department of Radiology, Medical Physics Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Ioanna TremiDNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece.ORCID 0000-0002-4711-8888
Alexandros G GeorgakilasDNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece.ORCID 0000-0002-5971-0010
Vassilis Kouloulias2nd Department of Radiology, Radiation Oncology Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Efstathios Efstathopoulos2nd Department of Radiology, Medical Physics Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0003-2747-3353
Kalliopi Platoni2nd Department of Radiology, Medical Physics Unit, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0003-2977-7895
National and Kapodistrian University of Athens · GRNational Technical University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Coronavirus disease 2019 (COVID-19) pandemic continues to spread worldwide with over 260 million people infected and more than 5 million deaths, numbers that are escalating on a daily basis. Frontline health workers and scientists diligently fight to alleviate life-threatening symptoms and control the spread of the disease. There is an urgent need for better triage of patients, especially in third world countries, in order to decrease the pressure induced on healthcare facilities. In the struggle to treat life-threatening COVID-19 pneumonia, scientists have debated the clinical use of ionizing radiation (IR). The historical literature dating back to the 1940s contains many reports of successful treatment of pneumonia with IR. In this work, we critically review the literature for the use of IR for both diagnostic and treatment purposes. We identify details including the computed tomography (CT) scanning considerations, the radiobiological basis of IR anti-inflammatory effects, the supportive evidence for low dose radiation therapy (LDRT), and the risks of radiation-induced cancer and cardiac disease associated with LDRT. In this paper, we address concerns regarding the effective management of COVID-19 patients and potential avenues that could provide empirical evidence for the fight against the disease.

Indexed as

Radiation, IonizingCOVID-19HumansLungPandemicsPneumonia, ViralPrognosisRadiation DosageRadiotherapy DosageRisk FactorsSARS-CoV-2anti-inflammatory treatmentchest CTCOVID-19imagingionizing radiationlow doselow dose radiation therapy (LDRT)radiotherapy

Identifiers

PMID35159277
PMCPMC8834503
OpenAlexW4210499245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.