Evidence map›Paper›PMID 35159232›Full record

ArticleCells2022

Cardiovascular Biomarker Profiles in Obesity and Relation to Normalization of Subclinical Cardiac Dysfunction after Bariatric Surgery.

Sanne M Snelder, Nadine Pouw, Yaar Aga, Manuel Castro Cabezas, L Ulas Biter, Felix Zijlstra, Isabella Kardys, Bas M van Dalen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06015620 (CoMOrbidities Resolution After Mini-GAstric Bypass Surgery for Morbid Obesity and Change in BOdy Composition), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06015620 recruitingnot on this mapstarted 2023, after this paper: background citation

CoMOrbidities Resolution After Mini-GAstric Bypass Surgery for Morbid Obesity and Change in BOdy Composition: A Prospective Cohort Study (MOGAMBO Study)

TypeobservationalSponsorAll India Institute of Medical Sciences, BhubaneswarRan2023 to 2027Enrolled35ConditionsMorbid Obesity, Type2diabetes, Sleep Apnea, HypothyroidismArmsMini gastric bypass surgery
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sanne M SnelderDepartment of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
Nadine PouwDepartment of Clinical Chemistry, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
Yaar AgaDepartment of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
Manuel Castro CabezasDepartment of Internal Medicine, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
L Ulas BiterDepartment of Surgery, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
Felix ZijlstraDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
Isabella KardysDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
Bas M van DalenDepartment of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.

Funding

BeterKeten xNovartis (Netherlands) x
6 · The paper itself

Abstract

aimsWe aimed to gain insight into the underlying pathophysiology of cardiac dysfunction in obesity patients and the improvement of cardiac function after weight loss.

methodsThis is a longitudinal study in which 92 cardiovascular biomarkers were measured by multiplex immunoassays in obesity patients without known cardiovascular disease, before and one year after bariatric surgery.

resultsOut of 100 eligible patients, 72 patients completed the follow-up. A total of 72 (78%) biomarkers changed significantly. The biomarkers with the highest relative changes represented processes linked mainly to insulin resistance and inflammation. In the patients with persistent subclinical cardiac dysfunction, the baseline values of 10 biomarkers were different from values in patients with normalization of cardiac function. Most of these biomarkers were linked to inflammation or atherosclerosis. Finally, a model was developed to investigate the relationship between changes in the biomarkers and persistent subclinical cardiac dysfunction. Seven biomarkers were retained in this model, mainly linked to inflammation, atherosclerosis, and hypercoagulability.

conclusionThe majority (78%) of cardiovascular biomarkers changed, pointing mainly to modulation of insulin resistance and inflammation. The baseline levels of 10 biomarkers, as well as pre- to post-bariatric surgery changes in seven biomarkers, were related to persistent subclinical cardiac dysfunction after bariatric surgery.

Indexed as

AtherosclerosisBariatric SurgeryHeart DiseasesInsulin ResistanceBiomarkersHumansInflammationLongitudinal StudiesObesityBiomarkersbariatric surgerybiomarkerscardiac dysfunctionobesity/obese

Identifiers

PMID35159232
PMCPMC8834585

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.