Evidence map›Paper›PMID 35159195›Full record

ArticleCells2022

Effect of FKBP12-Derived Intracellular Peptides on Rapamycin-Induced FKBP-FRB Interaction and Autophagy.

Carolina A Parada, Ivan Pires de Oliveira, Mayara C F Gewehr, João Agostinho Machado-Neto, Keli Lima, Rosangela A S Eichler, Lucia R Lopes, Luiz R G Bechara, Julio C B Ferreira, William T Festuccia and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Neurolysin Knockout Mice in a Diet-Induced Obesity Model.International journal of molecular sciences · 2023
    Article
  6. Article
  7. Genome-Wide Identification and Analysis of FKBP Gene Family in Wheat (International journal of molecular sciences · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Carolina A ParadaDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.
Ivan Pires de OliveiraDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.
Mayara C F GewehrDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.
João Agostinho Machado-NetoDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0002-2937-8109
Keli LimaDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0002-5498-7539
Rosangela A S EichlerDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.
Lucia R LopesDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-0530-7805
Luiz R G BecharaDepartments of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.
Julio C B FerreiraDepartments of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-2694-239X
William T FestucciaDepartments of Physiology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-4769-0806
Luciano CensoniDepartment of Physical Chemistry, Institute of Chemistry, University of Campinas, Campinas 13083-970, SP, Brazil.
Ivarne Luis S TersariolDepartment of Biochemistry, Paulista Medical School, São Paulo Federal University (UNIFESP), São Paulo 04021-001, SP, Brazil.ORCID 0000-0002-8399-4535
Emer S FerroDepartments of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-1651-9192
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de São Paulo · BR

Funding

National Council for Scientific and Technological Development 302809/2016-3São Paulo Research Foundation 2016/04000-3, 2019/07332-5, 2019/23864-7, 2019/23864-7 and 2019/27149-0
6 · The paper itself

Abstract

Intracellular peptides (InPeps) generated by proteasomes were previously suggested as putative natural regulators of protein-protein interactions (PPI). Here, the main aim was to investigate the intracellular effects of intracellular peptide VFDVELL (VFD7) and related peptides on PPI. The internalization of the peptides was achieved using a C-terminus covalently bound cell-penetrating peptide (cpp; YGRKKRRQRRR). The possible inhibition of PPI was investigated using a NanoBiT

Indexed as

SirolimusTacrolimus Binding Protein 1AAnimalsAutophagyFibroblastsHEK293 CellsHumansMechanistic Target of Rapamycin Complex 1MicePeptidesTacrolimusTacrolimus Binding ProteinsMechanistic Target of Rapamycin Complex 1PeptidesSirolimusTacrolimusTacrolimus Binding Protein 1ATacrolimus Binding Proteinsedgotypeintracellular peptidesmTORC1protein–protein interaction

Identifiers

PMID35159195
PMCPMC8834644
OpenAlexW4210255025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.