ReviewCells2022
Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle.
Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Global hotspots and research trends of radiation-induced skin injury: a bibliometric analysis from 2004 to 2023.Frontiers in oncology · 2024Pooled it
- Targeting E3 ubiquitin ligases: Mechanistic breakthroughs and novel clinical translation pathways for tumor radioimmunotherapy.Molecular cancer · 2026Review
- Real-time confocal imaging for evaluation of dose-dependent effects of gamma knife radiosurgery on U87 glioblastoma cell line.Journal of neuro-oncology · 2026Article
- Optotransduction Pathway, Exploring Connections with Inflammation.Biomolecules · 2026Article
- Insights into the Impact of Low-Dose Ionizing Radiation on Neurodegenerative Disease Progression in In Vivo Models.International journal of molecular sciences · 2026Review
- Microarray-Based Genomic Profiling in Low-Dose Radiation Research: Evidence, Limitations, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Syndrome of the trephined: from pathophysiology to cranioplasty - an updated narrative review.Brain & spine · 2026Review
- Low-dose radiation exposure and health outcomes among healthcare workers: a multi-center prospective cohort study.Journal of health, population, and nutrition · 2025Article
- Low-Dose radiation risk in medicine: a look at risk models, challenges, and future prospects.Zeitschrift fur medizinische Physik · 2025Review
- Impact of the ATM/Chk2 pathway and cell cycle phase on radiation-induced senescence in A549 human lung cancer cells.Biomedical reports · 2025Article
- Enhanced tumor retention and therapeutic potency in radionuclide therapy using GSH-induced self-assembling peptides.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Adverse Outcome Pathways Applied to Space Radiation Research.Environmental and molecular mutagenesis · 2025Review
- Preconditioning with Low-Dose Radiation Improves Antitumor Immunity and Survival in DC-Vaccinated Mice.Life (Basel, Switzerland) · 2025Article
- Short and long-term effects on the thyroid proteome after 131I exposure.Radiation protection dosimetry · 2025Article
- [Treatment strategy for severe radiation-induced ulcers near major blood vessels].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Observational
- Low-Dose Ionizing Radiation and Male Reproductive Immunity: Elucidating Subtle Modulations and Long-Term Health Implications.International journal of molecular sciences · 2025Review
- Mechanisms of Antitumor Activity of Low Doses of Radiation Associated with Activation of Cells' Defense System.Doklady. Biochemistry and biophysics · 2025Article
- Protective Role of Sphingosine-1-Phosphate During Radiation-Induced Testicular Injury.Antioxidants (Basel, Switzerland) · 2024Review
- Modulation of heat shock protein expression and cytokine levels in MCF-7 cells through photodynamic therapy.Lasers in medical science · 2024Article
- Late Effects of Ionizing Radiation on the Ultrastructure of Hepatocytes and Activity of Lysosomal Enzymes in Mouse Liver Irradiated In Vivo.Metabolites · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells exposed to ionizing radiation undergo a series of complex responses, including DNA damage, reproductive cell death, and altered proliferation states, which are all linked to cell cycle dynamics. For many years, a great deal of research has been conducted on cell cycle checkpoints and their regulators in mammalian cells in response to high-dose exposures to ionizing radiation. However, it is unclear how low-dose ionizing radiation (LDIR) regulates the cell cycle progression. A growing body of evidence demonstrates that LDIR may have profound effects on cellular functions. In this review, we summarize the current understanding of how LDIR (of up to 200 mGy) regulates the cell cycle and cell-cycle-associated proteins in various cellular settings. In light of current findings, we also illustrate the conceptual function and possible dichotomous role of p21
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.