Evidence map›Paper›PMID 35158980›Full record

ArticleCancers2022

Radiomics Features of the Spleen as Surrogates for CT-Based Lymphoma Diagnosis and Subtype Differentiation.

Johanna S Enke, Jan H Moltz, Melvin D'Anastasi, Wolfgang G Kunz, Christian Schmidt, Stefan Maurus, Alexander Mühlberg, Alexander Katzmann, Michael Sühling, Horst Hahn and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
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  5. Deep learning-derived splenic radiomics, genomics, and coronary artery disease.medRxiv : the preprint server for health sciences · 2024
    Article
  6. Article
  7. Article
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  10. Tumor classification of gastrointestinal liver metastases using CT-based radiomics and deep learning.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Johanna S EnkeDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Jan H MoltzFraunhofer Institute for Digital Medicine MEVIS, 28359 Bremen, Germany.
Melvin D'AnastasiDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Wolfgang G KunzDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.ORCID 0000-0002-5021-1952
Christian SchmidtDepartment of Medicine III, University Hospital, LMU Munich, 81377 Munich, Germany.
Stefan MaurusDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Alexander MühlbergCT R&D Image Analytics, Siemens Healthineers, 91301 Forchheim, Germany.
Alexander KatzmannCT R&D Image Analytics, Siemens Healthineers, 91301 Forchheim, Germany.ORCID 0000-0003-1958-1549
Michael SühlingCT R&D Image Analytics, Siemens Healthineers, 91301 Forchheim, Germany.
Horst HahnFraunhofer Institute for Digital Medicine MEVIS, 28359 Bremen, Germany.
Dominik NörenbergDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.ORCID 0000-0001-7726-9006
Thomas HuberDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
LMU Klinikum · DESiemens Healthineers (Germany) · DEFraunhofer Institute for Digital Medicine · DEHeidelberg University · DEMater Dei Hospital · MT

Funding

Federal Ministry of Education and Research FKZ 13GW0163B
6 · The paper itself

Abstract

The spleen is often involved in malignant lymphoma, which manifests on CT as either splenomegaly or focal, hypodense lymphoma lesions. This study aimed to investigate the diagnostic value of radiomics features of the spleen in classifying malignant lymphoma against non-lymphoma as well as the determination of malignant lymphoma subtypes in the case of disease presence-in particular Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), mantle-cell lymphoma (MCL), and follicular lymphoma (FL). Spleen segmentations of 326 patients (139 female, median age 54.1 +/- 18.7 years) were generated and 1317 radiomics features per patient were extracted. For subtype classification, we created four different binary differentiation tasks and addressed them with a Random Forest classifier using 10-fold cross-validation. To detect the most relevant features, permutation importance was analyzed. Classifier results using all features were: malignant lymphoma vs. non-lymphoma AUC = 0.86 (

Indexed as

computer aided diagnosismachine learningmalignant lymphomaquantitative imaging biomarkersradiomicssplenic involvementsubtype classification

Identifiers

PMID35158980
PMCPMC8833623
OpenAlexW4210569324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.