Evidence map›Paper›PMID 35158970›Full record

ArticleCancers2022

Plasma Thymidine Kinase Activity as a Novel Biomarker in Metastatic Melanoma Patients Treated with Immune Checkpoint Inhibitors.

Fernanda Costa Svedman, Marie Jalsenius, Veronica Höiom, Vitali Grozman, Mattias Bergqvist, Fabian Söderdahl, Hanna Eriksson, Samuel Rotstein, Lars Ny, Paolo A Ascierto and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Trial
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Fernanda Costa SvedmanDepartment of Oncology and Pathology, Karolinska Institutet, 171-77 Stockholm, Sweden.
Marie JalseniusTheme Cancer, Karolinska University Hospital, 171-76 Stockholm, Sweden.
Veronica HöiomDepartment of Oncology and Pathology, Karolinska Institutet, 171-77 Stockholm, Sweden.
Vitali GrozmanSection of Thoracic Radiology, Department of Imaging and Physiology, Karolinska University Hospital, 171-76 Stockholm, Sweden.
Mattias BergqvistBiovica International AB, Uppsala Science Park, 752-37 Uppsala, Sweden.
Fabian SöderdahlStatisticon AB, 753-22 Uppsala, Sweden.
Hanna ErikssonDepartment of Oncology and Pathology, Karolinska Institutet, 171-77 Stockholm, Sweden.
Samuel RotsteinTheme Cancer, Karolinska University Hospital, 171-76 Stockholm, Sweden.
Lars NyDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, 418-77 Gothenburg, Sweden.ORCID 0000-0003-3864-5958
Paolo A AsciertoDepartment of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", 80131 Napoli, Italy.
Suzanne Egyhazi BrageDepartment of Oncology and Pathology, Karolinska Institutet, 171-77 Stockholm, Sweden.
Hildur HelgadottirDepartment of Oncology and Pathology, Karolinska Institutet, 171-77 Stockholm, Sweden.
Karolinska University Hospital · SEBiovica (Sweden) · SEIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITKarolinska Institutet · SESahlgrenska University Hospital · SEStatisticon (Sweden) · SE

Funding

Radium Hemmets Research Funds 194092Stockholm County Council 20200638Swedish Cancer Society CAN 2017/503 and 20 0156 F
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CTLA-4 inhibitorimmune checkpoint inhibitorsipilimumabmelanomanivolumabPD-1 inhibitorpembrolizumabthymidine kinase

Identifiers

PMID35158970
PMCPMC8833501
OpenAlexW4210754753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.