Evidence map›Paper›PMID 35158906›Full record

ArticleCancers2022

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression.

Alice Blandino, Dominique Scherer, Trine B Rounge, Sinan U Umu, Felix Boekstegers, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales and 31 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. International collaborative research to improve gallbladder cancer prevention.Nature reviews. Gastroenterology & hepatology · 2025
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 10 countries.

Alice BlandinoStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-6808-1826
Dominique SchererStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0003-4430-296X
Trine B RoungeDepartment of Research, Cancer Registry of Norway, 0379 Oslo, Norway.
Sinan U UmuDepartment of Research, Cancer Registry of Norway, 0379 Oslo, Norway.ORCID 0000-0001-8081-7819
Felix BoekstegersStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-0587-7624
Carol Barahona PonceStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0001-9505-4965
Katherine MarcelainDepartment of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile.
Valentina Gárate-CalderónStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.
Melanie WaldenbergerResearch Unit Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Erik MoralesHospital Regional de Talca, Talca 3460000, Chile.
Armando RojasFacultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0000-0001-9911-7142
César MunozHospital Regional de Talca, Talca 3460000, Chile.
Javier RetamalesInstituto Nacional del Cáncer, Santiago 7500650, Chile.ORCID 0000-0001-7051-0362
Gonzalo de ToroHospital de Puerto Montt, Puerto Montt 5480000, Chile.
Olga BarajasDepartment of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile.
María Teresa RiveraHospital del Salvador, Santiago 7500922, Chile.
Analía CortésHospital del Salvador, Santiago 7500922, Chile.
Denisse LoaderHospital Padre Hurtado, Santiago 8880456, Chile.
Javiera SaavedraHospital Padre Hurtado, Santiago 8880456, Chile.
Lorena GutiérrezHospital San Juan de Dios, Santiago, 8320000, Chile.
Alejandro OrtegaHospital Regional, Arica 1000000, Chile.
Maria Enriqueta BertránUnidad Registro hospitalario de Cáncer, Hospital Base Valdivia, Valdivia 5090146, Chile.
Fernando GablerHospital San Borja Arriarán, Santiago 8320000, Chile.
Mónica CamposHospital San Borja Arriarán, Santiago 8320000, Chile.
Juan AlvaradoHospital Regional Guillermo Grant Benavente, Concepcion 4070386, Chile.
Fabrizio MoisánHospital Regional Guillermo Grant Benavente, Concepcion 4070386, Chile.
Loreto SpencerHospital Regional Guillermo Grant Benavente, Concepcion 4070386, Chile.
Bruno NerviDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Daniel E Carvajal-HausdorfFacultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7650568, Chile.
Héctor LosadaHospital de Temuco, Temuco 4780000, Chile.ORCID 0000-0002-8684-9675
Mauricio AlmauHospital de Rancagua, Rancagua 2820000, Chile.
Plinio FernándezHospital de Rancagua, Rancagua 2820000, Chile.
Ivan GallegosDepartment of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile.
Jordi OlloquequiDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
Macarena Fuentes-GuajardoDepartamento de Tecnología Médica, Facultad de Ciencias de la Salud, Tarapacá University, Arica 1000815, Chile.
Rolando Gonzalez-JoseInstituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn U9120ACD, Argentina.ORCID 0000-0002-8128-9381
Maria Cátira BortoliniInstituto de Biociências, Universidad Federal do Rio Grande do Sul, Puerto Alegre 15053, Brazil.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.ORCID 0000-0001-8348-0473
Andres Ruiz LinaresMinistry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200434, China.
Francisco RothhammerInstituto de Alta Investigación, Tarapacá University, Arica 1000000, Chile.
Justo Lorenzo BermejoStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-6568-5333
Heidelberg University · DECatholic University of the Maule · CLHospital Regional de Concepción · CLHospital Clínico de la Universidad de Chile · CLHospital del Salvador · CLHospital Padre Hurtado · CLHospital Regional Rancagua · CLHospital San Borja Arriarán · CLUniversity of Tarapacá · CLAix-Marseille Université · FRAustral University of Chile · CLCancer Registry of Norway · NOCentro Científico Tecnológico Patagónico · ARHelmholtz Zentrum München · DEHospital Base · CLHospital Regional de Arica Doctor Juan Noé Crevani · CLHospital San Juan de Dios · CLInstituto Nacional del Cáncer · CLPontificia Universidad Católica de Chile · CLUniversidad Autónoma de Chile · CL

Funding

Deutsche Forschungsgemeinschaft LO 1928/11-1German Academic Exchange Service 91778799Horizon 2020 research and innovation program 825741
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) play key roles in cell processes and are good candidates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. Here we integrate three separate datasets with information on lncRNA expression only, both lncRNA expression and genotype, and genotype information only to identify circulating lncRNAs associated with the risk of gallbladder cancer (

Indexed as

eQTLsgallbladder cancergenetic association studylncRNAsmolecular phenotypes

Identifiers

PMID35158906
PMCPMC8833674
OpenAlexW4210328494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.