Evidence map›Paper›PMID 35158896›Full record

ReviewCancers2022

Nonmalignant Features Associated with Inherited Colorectal Cancer Syndromes-Clues for Diagnosis.

Diana Haimov, Sari Lieberman, Sergi Castellvi-Bel, Maartje Nielsen, Yael Goldberg

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Diana HaimovRaphael Recanati Genetic Institute, Rabin Medical Center, Beilinson Hospital, Petach-Tikva 4941492, Israel.
Sari LiebermanMedical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 9103102, Israel.ORCID 0000-0003-1671-6444
Sergi Castellvi-BelDepartment of Gastroenterology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Hospital Clínic, 08035 Barcelona, Spain.ORCID 0000-0003-1217-5097
Maartje NielsenDepartment of Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-5351-1870
Yael GoldbergRaphael Recanati Genetic Institute, Rabin Medical Center, Beilinson Hospital, Petach-Tikva 4941492, Israel.ORCID 0000-0002-9855-9472
Rafael Advanced Defense Systems (Israel) · ILCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESLeiden University Medical Center · NLShaare Zedek Medical Center · IL

Funding

CERCA Program (Generalitat de Catalunya) and Agència de Gestió d'Ajuts Universitaris i de Recerca Generalitat de Catalunya, GRPRE 2017SGR21Fondo de Investigación Sanitaria/FEDER 20/00113Fundació La Marató de TV3 2019-202008-10Fundación Científica de la Asociación Española contra el Cáncer PRYGN211085CAST
6 · The paper itself

Abstract

Genetic diagnosis of affected individuals and predictive testing of their at-risk relatives, combined with intensive cancer surveillance, has an enormous cancer-preventive potential in these families. A lack of awareness may be part of the reason why the underlying germline cause remains unexplained in a large proportion of patients with CRC. Various extracolonic features, mainly dermatologic, ophthalmic, dental, endocrine, vascular, and reproductive manifestations occur in many of the cancer predisposition syndromes associated with CRC and polyposis. Some are mediated via the WNT,

Indexed as

colorectal cancerdiagnosisextracolonicgenetic predispositiongermlinemosaicismmTOR polyposisTGF-βWNT

Identifiers

PMID35158896
PMCPMC8833640
OpenAlexW4210764830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.