Evidence map›Paper›PMID 35158872›Full record

ArticleCancers2022

T- and B-Cells in the Inner Invasive Margin of Hepatocellular Carcinoma after Resection Associate with Favorable Prognosis.

Andriy Trailin, Lenka Červenková, Filip Ambrozkiewicz, Esraa Ali, Phanindra Kasi, Richard Pálek, Petr Hošek, Vladislav Třeška, Ondrej Daum, Zbyněk Tonar and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Spatial patterns and prognostic relevance of CD1aCancer immunology, immunotherapy : CII · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Andriy TrailinLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.ORCID 0000-0001-8888-0759
Lenka ČervenkováLaboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.
Filip AmbrozkiewiczLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.ORCID 0000-0001-6850-780X
Esraa AliLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.
Phanindra KasiDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarská 48, 30166 Pilsen, Czech Republic.
Richard PálekLaboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.
Petr HošekLaboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.ORCID 0000-0002-9359-4770
Vladislav TřeškaDepartment of Surgery and Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 80, 32300 Pilsen, Czech Republic.
Ondrej DaumSikl's Institute of Pathology, Faculty of Medicine and Teaching Hospital in Plzen, Charles University, ul. Dr. E. Beneše 13, 30599 Pilsen, Czech Republic.ORCID 0000-0002-0930-7071
Zbyněk TonarDepartment of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Karlovarská 48, 30166 Pilsen, Czech Republic.ORCID 0000-0002-7200-9894
Václav LiškaLaboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.
Kari HemminkiLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.ORCID 0000-0002-2769-3316
Charles University · CZGerman Cancer Research Center · DE

Funding

Charles University Research Fund Progres Q39European Union's Horizon 2020 research and innovation programme 856620Ministry of Health of the Czech Republic AZV NU21-03-00506
6 · The paper itself

Abstract

In this retrospective study on 67 patients with hepatocellular carcinoma (HCC), after tumor resection, we evaluated the significance of CD3+ and CD8+ T-lymphocytes and CD20+ B-lymphocytes in tumor and non-tumor liver for time to recurrence (TTR), disease-free survival (DFS) and overall survival. After immunohistochemical staining, the density of nucleated lymphocyte profiles (Q

Indexed as

B-cellsdisease-free survivalhepatocellular carcinomaheterogeneityprognosisstereologyT-cellstime to recurrencetumor-infiltrating lymphocytestumor invasive margin

Identifiers

PMID35158872
PMCPMC8833821
OpenAlexW4210455029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.