Evidence map›Paper›PMID 35158830›Full record

ArticleCancers2022

Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer.

Caner Yelek, Lionel Mignion, Adrien Paquot, Caroline Bouzin, Cyril Corbet, Giulio G Muccioli, Patrice D Cani, Bénédicte F Jordan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. A review of the impact of energy balance on triple-negative breast cancer.Journal of the National Cancer Institute. Monographs · 2023
    Review
  7. Mapping endocrine networks by stable isotope tracing.Current opinion in endocrine and metabolic research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Caner YelekBiomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.
Lionel MignionBiomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.
Adrien PaquotBioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.ORCID 0000-0002-4784-3510
Caroline BouzinIREC Imaging Platform, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.ORCID 0000-0003-0694-1947
Cyril CorbetPole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.ORCID 0000-0001-8795-9131
Giulio G MuccioliBioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.ORCID 0000-0002-1600-9259
Patrice D CaniMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.ORCID 0000-0003-2040-2448
Bénédicte F JordanBiomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.
UCLouvain · BEWalloon Excellence in Lifesciences and Biotechnology · BE

Funding

Actions de Recherches concertées-Communauté Française de Belgique ARC19/24-096Fund for Scientific Research EOS : program no. 30770923Fund for Scientific Research FNRS T.0030.21-PFund for Scientific Research Research Director, Research Associate and Televie grantsPatronage from the 'Pharmacies Servais' Study of the links between obesity and breast cancerWalloon Excellence in Lifesciences and Biotechnology WELBIO-CR-2019C-02R
6 · The paper itself

Abstract

Obesity is characterized by an excessive fat mass accumulation associated with multiple disorders, including impaired glucose homeostasis, altered adipokine levels, and hyperlipidemia. Despite clear associations between tumor progression and obesity, the effects of these disorders on tumor metabolism remain largely unknown. Thus, we studied the metabolic differences between tumors of obese and lean mice in murine models of triple-negative breast cancer (E0771 and PY8819). For this purpose, a real-time hyperpolarized 1-

Indexed as

breast cancerdynamic nuclear polarizationmetabolic fluxmetabolismNMR spectroscopyobesityTCA metabolites: carbon 13

Identifiers

PMID35158830
PMCPMC8833372
OpenAlexW4212775606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.