Evidence map›Paper›PMID 35158786›Full record

ArticleCancers2022

Immune Checkpoint Blockade for Metastatic Uveal Melanoma: Re-Induction following Resistance or Toxicity.

Elias A T Koch, Anne Petzold, Anja Wessely, Edgar Dippel, Anja Gesierich, Ralf Gutzmer, Jessica C Hassel, Sebastian Haferkamp, Katharina C Kähler, Harald Knorr and 21 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Uveal Melanoma: Changing Paradigms of Treatment.Ocular oncology and pathology · 2026
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Elias A T KochDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Anne PetzoldDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Anja WesselyDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0003-1940-5115
Edgar DippelDepartment of Dermatology, Ludwigshafen Medical Center, 67059 Ludwigshafen, Germany.
Anja GesierichDepartment of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany.
Ralf GutzmerSkin Cancer Center Minden, Department of Dermatology, Mühlenkreiskliniken AöR, Ruhr University Bochum Campus Minden, 32423 Minden, Germany.
Jessica C HasselSkin Cancer Center, Department of Dermatology and National Center for Tumor Diseases (NCT), University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0001-7575-6230
Sebastian HaferkampDepartment of Dermatology, University Hospital Regensburg, 93053 Regensburg, Germany.
Katharina C KählerDepartment of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Harald KnorrDepartment of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Nicole KreuzbergDepartment of Dermatology and Venereology, Skin Cancer Center, Center of Integrated Oncology (CIO) Köln Bonn, University Hospital of Cologne, 50937 Cologne, Germany.
Ulrike LeiterDepartment of Dermatology, Center for Dermatooncology, University Hospital Tübingen, 72056 Tübingen, Germany.ORCID 0000-0002-8019-1577
Carmen LoquaiDepartment of Dermatology, University Medical Center Mainz, 55131 Mainz, Germany.
Friedegund MeierSkin Cancer Center, University Cancer Center Dresden and National Center for Tumor Diseases & Department of Dermatology, University Hospital Carl Gustav Carus, 01307 Dresden, Germany.ORCID 0000-0003-4340-9706
Markus MeissnerDepartment of Dermatology, Venereology and Allergology, Goethe University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-5630-587X
Peter MohrDepartment of Dermatology, Elbeklinikum, 21614 Buxtehude, Germany.ORCID 0000-0002-7328-7407
Claudia PföhlerDepartment of Dermatology, Saarland University Medical School, 66421 Homburg, Saar, Germany.ORCID 0000-0003-0384-114X
Farnaz RahimiDepartment of Dermatology and Allergy, Munich University Hospital (LMU), 81377 Munich, Germany.
Dirk SchadendorfDepartment of Dermatology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-3524-7858
Beatrice SchellDepartment of Dermatology, SRH Wald-Klinikum Gera, 07548 Gera, Germany.
Max SchlaakCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, 10117 Berlin, Germany.ORCID 0000-0002-1663-8098
Patrick TerheydenDepartment of Dermatology, University of Lübeck, 23562 Lübeck, Germany.
Kai-Martin ThomsDepartment of Dermatology, University Medical Center Goettingen, 37075 Goettingen, Germany.
Beatrice Schuler-ThurnerDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0001-8653-5425
Selma UgurelDepartment of Dermatology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-9384-6704
Jens UlrichDepartment of Dermatology, Harzklinikum Dorothea Christiane Erxleben, 06484 Quedlinburg, Germany.
Jochen UtikalSkin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0001-5316-0241
Michael WeichenthalDepartment of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.ORCID 0000-0002-9060-4961
Fabian ZillerDepartment of Dermatology, DRK Krankenhaus Rabenstein, 09117 Chemnitz, Germany.
Carola BerkingDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0003-0229-8931
Markus V HepptDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0003-4603-1825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Re-induction with immune checkpoint blockade (ICB) needs to be considered in many patients with uveal melanoma (UM) due to limited systemic treatment options. Here, we provide hitherto the first analysis of ICB re-induction in UM. A total of 177 patients with metastatic UM treated with ICB were included from German skin cancer centers and the German national skin cancer registry (ADOReg). To investigate the impact of ICB re-induction, two cohorts were compared: patients who received at least one ICB re-induction (cohort A,

Indexed as

CTLA-4immune checkpoint blockadePD-1re-inductiontoxicitytreatment resistanceuveal melanoma

Identifiers

PMID35158786
PMCPMC8833453

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.