Evidence map›Paper›PMID 35158780›Full record

ArticleCancers2022

Intrinsic Cellular Susceptibility to Barrett's Esophagus in Adults Born with Esophageal Atresia.

Chantal A Ten Kate, Annelies de Klein, Bianca M de Graaf, Michail Doukas, Antti Koivusalo, Mikko P Pakarinen, Robert van der Helm, Tom Brands, Hanneke IJsselstijn, Yolande van Bever and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Chantal A Ten KateDepartment of Pediatric Surgery and Intensive Care Children, Erasmus MC-Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-9921-7776
Annelies de KleinDepartment of Clinical Genetics, Erasmus MC Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.
Bianca M de GraafDepartment of Clinical Genetics, Erasmus MC Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-9564-0283
Michail DoukasDepartment of Pathology, Erasmus MC, 3000 CA Rotterdam, The Netherlands.
Antti KoivusaloDepartment of Pediatric Surgery, University of Helsinki, Children's Hospital, 281, 000290 Helsinki, Finland.
Mikko P PakarinenDepartment of Pediatric Surgery, University of Helsinki, Children's Hospital, 281, 000290 Helsinki, Finland.ORCID 0000-0001-6016-6334
Robert van der HelmDepartment of Clinical Genetics, Erasmus MC Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.
Tom BrandsDepartment of Clinical Genetics, Erasmus MC Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.
Hanneke IJsselstijnDepartment of Pediatric Surgery and Intensive Care Children, Erasmus MC-Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.
Yolande van BeverDepartment of Clinical Genetics, Erasmus MC Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.
René M H WijnenDepartment of Pediatric Surgery and Intensive Care Children, Erasmus MC-Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.
Manon C W SpaanderDepartment of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, 3000 CA Rotterdam, The Netherlands.
Erwin BrosensDepartment of Clinical Genetics, Erasmus MC Sophia Children's Hospital, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8235-4010
Erasmus MC - Sophia Children’s Hospital · NLUniversity of Helsinki · FIErasmus MC · NLErasmus MC Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of Barrett's esophagus (BE) in adults born with esophageal atresia (EA) is four times higher than in the general population and presents at a younger age (34 vs. 60 years). This is (partly) a consequence of chronic gastroesophageal reflux. Given the overlap between genes and pathways involved in foregut and BE development, we hypothesized that EA patients have an intrinsic predisposition to develop BE. Transcriptomes of Esophageal biopsies of EA patients with BE (

Indexed as

acid sensitivityesophageal carcinomaesophagitisgenetic predispositioninflammatory response

Identifiers

PMID35158780
PMCPMC8833471
OpenAlexW4207000159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.