Evidence map›Paper›PMID 35158773›Full record

ArticleCancers2022

NSAIDs Overcome

Hua Li, Noah D Peyser, Yan Zeng, Patrick K Ha, Daniel E Johnson, Jennifer R Grandis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hua LiDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143, USA.
Noah D PeyserDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4529-8325
Yan ZengDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-5496-4468
Patrick K HaDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143, USA.
Daniel E JohnsonDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143, USA.
Jennifer R GrandisDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143, USA.
University of California, San Francisco · US

Funding

Integrating genomics and the protein interactome for HPV+ head and neck cancer therapyR35CA231998 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2018 to 2024
$6.2M
PI3K Pathway Mutations in Head and Neck CancerR01DE023685 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRANDIS, JENNIFER RUBIN, JOHNSON, DANIEL E · 2014 to 2023
$5.1M
American Cancer Society J.R.G.NCI NIH HHS R35 CA231998NCI NIH HHS R35CA231998NIDCR NIH HHS R01 DE023685NIDCR NIH HHS R01DE023685
6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) inhibitors are approved by the Food and Drug Administration (FDA) but remain under active clinical investigation for the treatment of both newly diagnosed and recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). Despite EGFR expression in the majority of HNSCC tumors, the levels of total or phosphorylated EGFR have not consistently been correlated with a response to EGFR targeting agents. The lack of predictive biomarkers represents a major obstacle to successful use of these drugs. Activation of phosphatidylinositol 3-kinase (PI3K) signaling by mutation of the

Indexed as

EGFRNSAIDPIK3CA

Identifiers

PMID35158773
PMCPMC8833811
OpenAlexW4207061847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.