ArticleEcotoxicology and environmental safety2022
The association between urinary glyphosate and aminomethyl phosphonic acid with biomarkers of oxidative stress among pregnant women in the PROTECT birth cohort study.
Article in Ecotoxicology and environmental safety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study.American journal of obstetrics and gynecology · 2023Pooled it
- Measured exposures to glyphosate in applicators and the general population: an updated review of the scientific literature since 2020.Pest management science · 2025Review
- Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study.Journal of exposure science & environmental epidemiology · 2025Article
- Urinary Glyphosate Concentrations and Serum Sex Hormones in a Nationally Representative U.S. Sample: NHANES 2017-2018.Life (Basel, Switzerland) · 2025Article
- Article
- Sociodemographic and dietary determinants of glyphosate exposure in a NYC-based pregnancy cohort.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies.International journal of environmental research and public health · 2024Review
- Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil.Environmental science & technology · 2024Article
- Glyphosate and a glyphosate-based herbicide dysregulate the epigenetic landscape of Homeobox A10 (Frontiers in toxicology · 2024Article
- Glyphosate-based herbicide metabolic profiles in human urine samples through proton nuclear magnetic resonance analysis.ADMET & DMPK · 2024Article
- Glyphosate Use and Mosaic Loss of Chromosome Y among Male Farmers in the Agricultural Health Study.Environmental health perspectives · 2023Article
- Urinary glyphosate and AMPA levels in a cross-sectional study of postmenopausal women: Associations with organic eating behavior and dietary intake.International journal of hygiene and environmental health · 2023Article
- Peer review of the pesticide risk assessment of the active substance glyphosate.EFSA journal. European Food Safety Authority · 2023Review
- Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis.Environmental toxicology and pharmacology · 2023Article
- Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study.Journal of the National Cancer Institute · 2023Article
- Pre-Conceptional Exposure to Glyphosate Affects the Maternal Hepatic and Ovarian Proteome.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies.Environmental health : a global access science source · 2022Observational
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11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundGlyphosate is a widely used herbicide in global agriculture. Glyphosate and its primary environmental degradate, aminomethyl phosphonic acid (AMPA), have been shown to disrupt endocrine function and induce oxidative stress in in vitro and animal studies. To our knowledge, these relationships have not been previously characterized in epidemiological settings. Elevated urinary levels of glyphosate and AMPA may be indicative of health effects caused by previous exposure via multiple mechanisms including oxidative stress.
methodsGlyphosate and AMPA were measured in 347 urine samples collected between 16 and 20 weeks gestation and 24-28 weeks gestation from pregnant women in the PROTECT birth cohort. Urinary biomarkers of oxidative stress, comprising 8-isoprostane-prostaglandin-F2α (8-iso-PGF2α), its metabolite 2,3-dinor-5,6-dihydro-15-F
resultsNo significant differences in exposure or oxidative stress biomarker concentrations were observed between study visits. An interquartile range (IQR) increase in AMPA was associated with 9.5% (95% CI: 0.5-19.3%) higher 8-iso-PGF2α metabolite concentrations. Significant linear trends were also identified when examining tertiles of exposure variables. Compared to the lowest exposure group, the second and third tertiles of AMPA were significantly associated with 12.8% (0.6-26.5%) and 15.2% (1.8-30.3%) higher 8-isoprostane metabolite, respectively. An IQR increase in glyphosate was suggestively associated with 4.7% (-0.9 to 10.7%) higher 8-iso-PGF2α.
conclusionsUrinary concentrations of the main environmental degradate of glyphosate, AMPA, were associated with higher levels of certain oxidative stress biomarkers. Associations with glyphosate reflected similar trends, although findings were not as strong. Additional research is required to better characterize the association between glyphosate exposure and biomarkers of oxidative stress, as well as potential downstream health consequences.
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