Evidence map›Paper›PMID 35158041›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2022

β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.

Maryam Honarbakhsh, Kiana Malta, Aaron Ericsson, Chelsee Holloway, Youn-Kyung Kim, Ulrich Hammerling, Loredana Quadro

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Antioxidants (Basel, Switzerland) · 2026
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  9. Whey Protein Isolate-Foods (Basel, Switzerland) · 2023
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maryam HonarbakhshDepartment of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, NJ, USA.
Kiana MaltaDepartment of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, NJ, USA.
Aaron EricssonDepartment of Veterinary Pathobiology, University of Missouri Metagenomics Center, University of Missouri, MO, USA.
Chelsee HollowayDepartment of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, NJ, USA; Graduate Program in Endocrinology and Animal Science, Rutgers University, NJ, USA.
Youn-Kyung KimDepartment of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, NJ, USA.
Ulrich HammerlingDepartment of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, NJ, USA.
Loredana QuadroDepartment of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, NJ, USA. Electronic address: lquadro@sebs.rutgers.edu.
Rutgers Sexual and Reproductive Health and Rights · NLMissouri College · US

Funding

Role of Lipoprotein Assembly in Maternal-Fetal Transport of Beta-CaroteneR01HD094778 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI HUSSAIN, M MAHMOOD, QUADRO, LOREDANA · 2019 to 2023
$1.9M
The asymmetric cleavage of beta-carotene in mammalian embryonic developmentR01HD083331 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI QUADRO, LOREDANA · 2016 to 2020
$1.6M
Impact of gut microbiota and segmented filamentous bacteria on colitis-associated colorectal cancerK01OD019924 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI ERICSSON, AARON · 2016 to 2020
$573k
NICHD NIH HHS R01 HD083331NICHD NIH HHS R01 HD094778NIH HHS K01 OD019924
6 · The paper itself

Abstract

Vitamin A deficiency (VAD) results in intestinal inflammation, increased redox stress and reactive oxygen species (ROS) levels, imbalanced inflammatory and immunomodulatory cytokines, compromised barrier function, and perturbations of the gut microbiome. To combat VAD dietary interventions with β-carotene, the most abundant precursor of vitamin A, are recommended. However, the impact of β-carotene on intestinal health during VAD has not been fully clarified, especially regarding the VAD-associated intestinal dysbiosis. Here we addressed this question by using Lrat

Indexed as

Intestinal DiseasesVitamin A DeficiencyAnimalsbeta CaroteneDisease Models, AnimalDysbiosisInflammationMiceVitamin Abeta CaroteneVitamin AIntestineMicrobiomeRetinoidsVitamin A deficiencyβ-carotene

Identifiers

PMID35158041
PMCPMC9940628
OpenAlexW4211045068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.