Evidence map›Paper›PMID 35157807›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2022

Fsp27 plays a crucial role in muscle performance.

Mark Slayton, Bijinu Balakrishnan, Abhishek Gupta, Scott Jobe, Ishika Puri, Savannah Neely, Yoshikazu Tamori, David W Russ, Gozde Yildirim, Shoshana Yakar and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. The ApoA5-Cidec axis: keeping fibrosis and MASLD at bay.Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Mark SlaytonDepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Bijinu BalakrishnanDepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Abhishek GuptaDepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Scott JobeOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Ishika PuriHonors Tutorial College, Ohio University, Athens, Ohio.
Savannah NeelyCollege of Arts and Sciences, Ohio University, Athens, Ohio.
Yoshikazu TamoriDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
David W RussSchool of Physical Therapy and Rehabilitation Sciences, USF Health Morsani College of Medicine, University of Southern Florida, Tampa, Florida.
Gozde YildirimDepartment of Molecular Pathobiology, New York University College of Dentistry, New York City, New York.
Shoshana YakarDepartment of Molecular Pathobiology, New York University College of Dentistry, New York City, New York.
Vishva M SharmaDepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Vishwajeet PuriDepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Ohio University · USNew York University · USFlorida State University · USKobe University · JPUniversity of South Florida · US

Funding

Identifying a novel regulatory pathway of vascular function in obesityR01HL140836 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, PURI, VISHWAJEET · 2018 to 2021
$2.2M
Cide Proteins and Regulation of Energy ExpenditureR01DK101711 · NIDDK · OHIO UNIVERSITY ATHENS · PI PURI, VISHWAJEET · 2014 to 2016
$1.1M
Skyscan 1172 Ex-vivo MicroComputed Tomography SystemS10OD010751 · OD · NEW YORK UNIVERSITY · PI PARTRIDGE, NICOLA C · 2013 to 2013
$326k
NHLBI NIH HHS R01 HL140836NIDDK NIH HHS R01 DK101711NIH HHS S10 OD010751
6 · The paper itself

Abstract

Fsp27 was previously identified as a lipid droplet-associated protein in adipocytes. Various studies have shown that it plays a role in the regulation of lipid homeostasis in adipose tissue and liver. However, its function in muscle, which also accumulate and metabolize fat, remains completely unknown. Our present study identifies a novel role of Fsp27 in muscle performance. Here, we demonstrate that Fsp27

Indexed as

AdipocytesLipid DropletsAdipose TissueAnimalsFemaleMaleMiceMusclesProteinsProteinsCideaCidecdiabetesfat metabolismlipid dropletslipidsobesity

Identifiers

PMID35157807
PMCPMC8957325
OpenAlexW4213149602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.