Evidence map›Paper›PMID 35157708›Full record

ArticlePloS one2022

Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon.

Jari Torniainen, Aapo Ristaniemi, Jaakko K Sarin, Mithilesh Prakash, Isaac O Afara, Mikko A J Finnilä, Lauri Stenroth, Rami K Korhonen, Juha Töyräs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jari TorniainenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-4953-4508
Aapo RistaniemiDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Jaakko K SarinDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Mithilesh PrakashA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Isaac O AfaraDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Mikko A J FinniläResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Lauri StenrothDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Rami K KorhonenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Juha TöyräsDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
University of Eastern Finland · FIQueensland University of Technology · AUUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee ligaments and tendons play an important role in stabilizing and controlling the motions of the knee. Injuries to the ligaments can lead to abnormal mechanical loading of the other supporting tissues (e.g., cartilage and meniscus) and even osteoarthritis. While the condition of knee ligaments can be examined during arthroscopic repair procedures, the arthroscopic evaluation suffers from subjectivity and poor repeatability. Near infrared spectroscopy (NIRS) is capable of non-destructively quantifying the composition and structure of collagen-rich connective tissues, such as articular cartilage and meniscus. Despite the similarities, NIRS-based evaluation of ligament composition has not been previously attempted. In this study, ligaments and patellar tendon of ten bovine stifle joints were measured with NIRS, followed by chemical and histological reference analysis. The relationship between the reference properties of the tissue and NIR spectra was investigated using partial least squares regression. NIRS was found to be sensitive towards the water (R2CV = .65) and collagen (R2CV = .57) contents, while elastin, proteoglycans, and the internal crimp structure remained undetectable. As collagen largely determines the mechanical response of ligaments, we conclude that NIRS demonstrates potential for quantitative evaluation of knee ligaments.

Indexed as

AnimalsCattleCollateral LigamentsElastinPatellar LigamentProteoglycansSpectroscopy, Near-InfraredStifleElastinProteoglycans

Identifiers

PMID35157708
PMCPMC8843223
OpenAlexW4212895688

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.