Evidence map›Paper›PMID 35157706›Full record

ArticlePloS one2022

Hotspot analysis by confocal microscopy can help to differentiate challenging melanocytic skin lesions.

Raquel de Paula Ramos Castro, Juliana Casagrande Tavoloni Braga, Mariana Petaccia de Macedo, Clóvis Antonio Lopes Pinto, José Humberto Tavares Guerreiro Fregnani, Gisele Gargantini Rezze

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Raquel de Paula Ramos CastroDepartment of Cutaneous Oncology, AC Camargo Cancer Center, São Paulo, Brazil.ORCID 0000-0003-1774-6581
Juliana Casagrande Tavoloni BragaDepartment of Cutaneous Oncology, AC Camargo Cancer Center, São Paulo, Brazil.
Mariana Petaccia de MacedoDepartment of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
Clóvis Antonio Lopes PintoDepartment of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
José Humberto Tavares Guerreiro FregnaniTeaching and Research Institute, AC Camargo Cancer Center, São Paulo, Brazil.
Gisele Gargantini RezzeDermaimage Medical Associates, São Paulo, Brazil.
AC Camargo Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some melanocytic lesions do not present enough clinical and dermoscopic features to allow ruling out a possible melanoma diagnosis. These "doubtful melanocytic lesions" pose a very common and challenging scenario in clinical practice and were selected at this study for reflectance confocal microscopy evaluation and subsequent surgical excision for histopathological diagnosis. The study included 110 lesions and three confocal features were statistically able to distinguish benign melanocytic lesions from melanomas: "peripheral hotspot at dermo-epidermal junction", "nucleated roundish cells at the dermo-epidermal junction" and "sheet of cells". The finding of a peripheral hotspot (atypical cells in 1mm2) at the DEJ is highlighted because has not been previously reported in the literature as a confocal feature related to melanomas.

Indexed as

Diagnosis, DifferentialHumansMelanomaMicroscopy, ConfocalNevus, PigmentedRetrospective StudiesSensitivity and Specificity

Identifiers

PMID35157706
PMCPMC8843198
OpenAlexW4213371534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.