ArticleAlcoholism, clinical and experimental research2022
Prenatal alcohol exposure and mental health at midlife: A preliminary report on two longitudinal cohorts.
Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Sensitive periods for prenatal alcohol exposure shape internalizing symptoms across development.medRxiv : the preprint server for health sciences · 2026Article
- Neurodevelopmental impacts of unique postnatal adversity subgroups in children with prenatal alcohol exposure.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2026Article
- Impact of adverse postnatal environment on emotional regulation and neuroimmune function in adolescent rats prenatally exposed to alcohol.Neurobiology of stress · 2026Article
- Prenatal Alcohol Exposure: Impact on Neuroimmune Function in the Stress Response and Pain.Advances in experimental medicine and biology · 2026Review
- Anxiety, Depression, and Emotional Dysregulation Following Prenatal Substance Exposure.Advances in experimental medicine and biology · 2026Review
- Role of gut microbiota and its functional products in prenatal alcohol-induced anxiety-like behavior.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Dysregulation of immune system markers, gut microbiota and short-chain fatty acid production following prenatal alcohol exposure: A developmental perspective.Neurochemistry international · 2025Article
- Neuroprotective Role of DING protein in Fetal Alcohol Spectrum Disorders and Depression.Obstetrics and gynecology research · 2025Article
- Fetal Alcohol Spectrum Disorders.Current topics in behavioral neurosciences · 2025Review
- Prenatal alcohol exposure and health at midlife: Self-reported health outcomes in two cohorts.Alcohol, clinical & experimental research · 2024Article
- Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development.Neuroscience and biobehavioral reviews · 2024Review
- Independent and Combined Effects of Prenatal Alcohol Exposure and Prenatal Stress on Fetal HPA Axis Development.International journal of molecular sciences · 2024Article
- Parenting by individuals with fetal alcohol spectrum disorders and neurobehavioral outcomes in their offspring.Alcohol, clinical & experimental research · 2024Article
- Racial and ethnic disparities in psychological care for individuals with FASD: a dis/ability studies and critical race theory perspective toward improving prevention, assessment/diagnosis, and intervention.Frontiers in public health · 2024Article
- Subcortical volume in middle-aged adults with fetal alcohol spectrum disorders.Brain communications · 2024Article
- Brain Volume in Fetal Alcohol Spectrum Disorders Over a 20-Year Span.JAMA network open · 2023Article
- The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan.Frontiers in neuroendocrinology · 2023Review
- Prenatal alcohol exposure and cognition at midlife: Evidence of fluid cognition deficits in two cohorts.Alcohol, clinical & experimental research · 2023Article
- Adverse childhood experiences in children with fetal alcohol spectrum disorders and their effects on behavior.Alcohol, clinical & experimental research · 2023Article
- Comparison of three systems for the diagnosis of fetal alcohol spectrum disorders in a community sample.Alcohol, clinical & experimental research · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAlthough the effects of prenatal alcohol exposure (PAE) have been studied extensively, there is relatively little information available on adult mental health functioning among exposed individuals. The current study compares the self-reported midlife mental health status of individuals who were prenatally exposed to alcohol and diagnosed in childhood with the effects of this exposure with that of unexposed individuals.
methodsParticipants (N = 292) were recruited from two longitudinal cohorts in Atlanta and Seattle and asked to complete an Adult Health Questionnaire that surveyed their current health and mental health status. The questionnaire was completed either in-person or remotely and included questions about current symptoms of depression and anxiety and mental health disorder diagnoses. The analysis compared a Nonexposed Contrast group to those in two exposure groups: (1) Alcohol Exposed with Fetal Alcohol Effect but not meeting criteria for Fetal Alcohol Syndrome (FAS) and (2) Alcohol Affected and meeting criteria for FAS.
resultsBoth alcohol-exposed groups reported higher levels of current depressive symptoms and a higher prevalence of diagnoses of depression, anxiety, bipolar disorder, and/or attention deficit/hyperactivity disorder. No differences were noted for psychotic disorders. PAE was also associated with greater environmental stressors, including higher levels of adverse childhood events and lower current socioeconomic status. Path analyses suggested that PAE was indirectly related to mood disorders with its effects being mediated by other environmental factors.
conclusionsPAE is associated with greater rates of mental health disorders in middle adulthood. These outcomes appear to result from multiple stressors that affect individuals made vulnerable by their early alcohol exposure. Clinical outcomes could be improved by prevention efforts directed at preventing prenatal alcohol use and reducing environmental stressors later in life, and by the early identification of PAE and its effects.
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