ArticleArchives of microbiology2022
Characterization and biological activities of melanin pigment from root endophytic fungus, Phoma sp. RDSE17.
Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Fungal melanin as a bioactive biopolymer: structural diversity, oxidative stress modulation, anticancer mechanisms, and therapeutic perspectives.RSC advances · 2026Review
- Microbial production of eumelanin from a desert-derived Aspergillus terreus: statistical optimization, comprehensive characterization, and in silico insights into breast cancer-associated targets.Microbial cell factories · 2026Article
- Toxicological Assessment and Dual Protective Roles ofJournal of fungi (Basel, Switzerland) · 2026Article
- Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach.World journal of microbiology & biotechnology · 2026Review
- Article
- Comparison and Analysis of Resistance Differences inJournal of fungi (Basel, Switzerland) · 2025Article
- The Enigmatic World of Fungal Melanin: A Comprehensive Review.Journal of fungi (Basel, Switzerland) · 2023Review
- Characterization and Biological Activities of Melanin from the Medicinal FungiInternational journal of molecular sciences · 2023Article
- Efficient production and characterization of melanin fromFrontiers in microbiology · 2023Article
- Melanin of fungi: from classification to application.World journal of microbiology & biotechnology · 2022Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Melanins are high molecular weight hydrophobic pigments which have gained popularity for their role in virulence against different pathogens. In the present study, we isolated and characterized the melanin pigment produced by a dark septate endophyte fungus Phoma sp. RDSE17, which was associated with the roots of an indigenous Oryza sativa cv. 'Chakhao amubi' in Manipur, Northeast India. The biological properties of purified melanin from the fungus were evaluated for their antioxidant, antimicrobial and anticancerous activities. The pigment was extracted from Phoma sp. by alkaline-acid hydrolysis method and confirmed as melanin through physico-chemical tests and spectral (UV, FTIR, and EPR) analysis. The analyses of the elemental composition indicated that the pigment possessed a low percentage of nitrogen (N) contents, and therefore, would not fall under DOPA class of melanin. Exposure of the fungus to melanin pathway inhibitors revealed a positive melanin inhibition by tricyclazole, but not by kojic acid. Thus, the melanin from Phoma sp. may be a member of the DHN family. Moreover, the purified melanin showed high DPPH (1, 1-Diphenyl-2-picrylhydrazyl) free radical-scavenging activity with an EC
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