Evidence map›Paper›PMID 35156991›Full record

ArticleInvestigative ophthalmology & visual science2022

Choroidal Caverns in Stargardt Disease.

Dario Pasquale Mucciolo, Dario Giorgio, Myrta Lippera, Valeria Dattilo, Ilaria Passerini, Elisabetta Pelo, Andrea Sodi, Gianni Virgili, Fabrizio Giansanti, Vittoria Murro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Genome-Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  3. Article
  4. Article
  5. The Role of the Choroid in Stargardt Disease.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dario Pasquale MuccioloDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Dario GiorgioDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Myrta LipperaDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Valeria DattiloDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Ilaria PasseriniDepartment of Genetic Diagnosis, Careggi Teaching Hospital, Florence, Italy.
Elisabetta PeloDepartment of Genetic Diagnosis, Careggi Teaching Hospital, Florence, Italy.
Andrea SodiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Gianni VirgiliDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Fabrizio GiansantiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Vittoria MurroDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report choroidal caverns in patients affected by recessive Stargardt disease (STGD1) and to investigate its clinical features. Methods: Retrospective analysis of STGD1 patients recruited at the Regional Reference Center for Hereditary Retinal Degenerations at the Eye Clinic in Florence from 2012 to 2017. Patients included in the study underwent a complete ophthalmic examination including best-corrected visual acuity, color fundus photography, fundus autofluorescence, optical coherence tomography (OCT) and OCT angiography. Results: Eighty-six patients (172 eyes) were included in the study. Twenty-three eyes (13.3%) of 21 patients presented choroidal caverns. The total number of detected choroidal caverns was 63. Choroidal caverns were only present in patients with stage III and IV STGD. Interestingly, patients with choroidal caverns presented larger macular atrophy (20.53 ± 16.9 mm2 vs. 18.11 ± 20.39 mm2), worse visual acuity (1.03 ± 0.29 vs. 0.83 ± 0.26), and a thinner choroidal thickness (245.9 ± 88.7 vs. 266.0 ± 110.5 µm). Conclusions: Choroidal caverns are present only in the advanced stage of STGD1, and a possible degenerative origin of the finding has been hypothesized.

Indexed as

AdolescentAdultAgedAged, 80 and overATP-Binding Cassette TransportersChoroid DiseasesComputed Tomography AngiographyFemaleHumansMaleMiddle AgedOptical ImagingRetrospective StudiesStargardt DiseaseTomography, Optical CoherenceVisual AcuityABCA4 protein, humanATP-Binding Cassette Transporters

Identifiers

PMID35156991
PMCPMC8857610
OpenAlexW4212942581

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.