Observational studyOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2022
All retinas are not created equal: Fovea-to-macula thickness ratio and foveal microvasculature in healthy young children.
Observational study in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Retinal vascular reactivity in carriers of X-linked inherited retinal disease - a study using optical coherence tomography angiography.Frontiers in ophthalmology · 2024Article
- Superficial capillary plexus vessel density/deep capillary plexus vessel density ratio in healthy eyes.BMC ophthalmology · 2022Article
- All retinas are not created equal: Fovea-to-macula thickness ratio and foveal microvasculature in healthy young children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Observational
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Authors and funding
6 authors.
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Abstract
purposeMarkers for the relationships between structural and microvasculature measures given by optical coherence tomography angiography are necessary to increase the diagnostic and prognostic value of this technique. The aim of this study was to investigate relationships between structural and microvasculature measures around the fovea in healthy eyes of healthy children.
methodsObservational cross-sectional study involving children aged 8-17 years, born at full-term, with no eye disease. The better of two 3 × 3 mm macular scans obtained with a Cirrus 5000HD-OCT was analysed. Images were corrected for lateral magnification errors. Vessel density and perfusion were measured with ImageJ/Fiji software for the superficial capillary plexus. Structural measures including foveal and macular thicknesses were performed manually.
resultsThe sample included 86 participants, 51 (59%) females. Mean age was 12.4 years (SD = 2.5); mean best-corrected acuity was -0.10 logMAR (SD = 0.09); mean refractive error was +0.59 D (SD = 1.3) and mean axial length was 23.1 mm (SD = 0.86). Mean area of the foveal avascular zone (AFAZ) was 0.20 mm
conclusionIn this study, foveal thickness, FMTR and foveal microvasculature measurements were correlated. Clinicians need to be aware that shallow foveal pits and persistent foveal microvasculature are likely to occur in optical coherence tomography angiography images. In healthy eyes from healthy children, an atypical high FMTR and a small AFAZ may be associated with incomplete foveal development. The mechanism and functional implications of this remain unknown.
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