Evidence map›Paper›PMID 35156712›Full record

ArticleThe Journal of physiology2022

Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats.

Josif Vidimce, Johara Pillay, Onne Ronda, Ai-Ching Boon, Evan Pennell, Kevin J Ashton, Theo H van Dijk, Karl-Heinz Wagner, Henkjan J Verkade, Andrew C Bulmer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Josif VidimceSchool of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia.
Johara PillaySchool of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia.
Onne RondaPediatric Gastroenterology/Hepatology, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ai-Ching BoonSchool of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia.
Evan PennellSchool of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia.
Kevin J AshtonFaculty of Health Science and Medicine, Bond University, Gold Coast, Australia.ORCID 0000-0001-6106-3425
Theo H van DijkDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-2713-049X
Karl-Heinz WagnerDepartment of Nutritional Sciences and Research Platform Active Ageing, University of Vienna, Vienna, Austria.
Henkjan J VerkadePediatric Gastroenterology/Hepatology, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Andrew C BulmerSchool of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia.ORCID 0000-0002-2994-7893
Griffith University · AUUniversity Medical Center Groningen · NLBond University · AUUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating bilirubin is associated with reduced serum cholesterol concentrations in humans and in hyperbilirubinaemic Gunn rats. However, mechanisms contributing to hypocholesterolaemia remain unknown. Therefore, this study aimed to investigate cholesterol synthesis, transport and excretion in mutant Gunn rats. Adult Gunn and control rats were assessed for daily faecal sterol excretion using metabolic cages, and water was supplemented with [1-

Indexed as

Gilbert DiseaseHypercholesterolemiaAnimalsBilirubinCholesterolFemaleHyperbilirubinemiaLipoproteins, LDLLiverMaleRatsRats, GunnReceptors, LDLSex CharacteristicsSterolsBilirubinCholesterolLipoproteins, LDLReceptors, LDLSterolsbile acid metabolismcholesterol metabolismGilbert's syndromeLDL receptorlipidSREBPUGT1A1unconjugated bilirubin

Identifiers

PMID35156712
PMCPMC9310728
OpenAlexW4213248057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.