Evidence map›Paper›PMID 35156429›Full record

ArticleTherapeutic advances in respiratory disease

In-hospital blood collection increases the rate of indeterminate results in interferon-gamma release assays.

Yuki Osakabe, Fumihiro Yamaguchi, Ayako Suzuki, Haruka Kitano, Mina Hiraiwa, Yo Shiratori, Shota Onozaki, Mari Nakamoto, Saori Kawamura, Miku Kosuge and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuki OsakabeDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Fumihiro YamaguchiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.ORCID 0000-0003-1611-6991
Ayako SuzukiDepartment of Pharmacy, Showa University Fujigaoka Hospital, Yokohama, Japan.
Haruka KitanoDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Mina HiraiwaDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Yo ShiratoriDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Shota OnozakiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Mari NakamotoDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Saori KawamuraDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Miku KosugeDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Kenji AtarashiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Hidekazu ChoDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Shohei ShimizuDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Akira FujishimaDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Yusuke ShikamaDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interferon (IFN)-γ release assay (IGRA) has recently been established as a method to evaluate the infection status of tuberculosis instead of the tuberculin skin test. However, indeterminate results can create challenges to interpretation. The IGRA has been available in Japan since 2005, including the recently launched QuantiFERON-TB Gold Plus (QFT-plus) assay.

objectivesThe aim of this study was to investigate the clinical features and predictors of indeterminate results by the QFT-plus test in routine practice.

methodsThis was a cross-sectional study of 1258 patients. Multivariate logistic regression models were employed to investigate the clinical factors related to indeterminate results by the QFT-plus.

resultsOverall, 91.8% of results were found to be conclusive and 8.2% were indeterminate. The QFT-plus indeterminate results were predominantly due to a low level of IFN-γ production by mitogens. Multivariate analysis indicated that an indeterminate result was significantly associated with age, sex, corticosteroid use, autoimmune disease, and inpatient setting.

conclusionCertain types of individuals are at higher risk of an indeterminate IGRA result. The QFT-plus test for hospitalized patients should be avoided as much as possible, and it is better to perform the test for those patients in outpatient settings.

Indexed as

Latent TuberculosisMycobacterium tuberculosisTuberculosisCross-Sectional StudiesHospitalsHumansInterferon-gamma Release TestsTuberculin Testinpatient settinginterferon-γ release assayMycobacterium tuberculosisQuantiFERON-TB Gold Plus

Identifiers

PMID35156429
PMCPMC8848041

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.