ReviewPaediatric anaesthesia2022
Down syndrome and the autonomic nervous system, an educational review for the anesthesiologist.
Review in Paediatric anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.Journal of sleep research · 2025Article
- Review
- Cerebral Blood Flow Abnormalities in Down Syndrome Regression Disorder.Pediatric neurology · 2025Observational
- Sedation for transthoracic echocardiography in children with Down syndrome: a propensity score-weighted retrospective cohort study.European journal of medical research · 2025Article
- Prospective Observational Study of Sympathetic Failure as a Mechanism Associated with Bradycardia During Induction of General Anesthesia in Children with Down Syndrome.The journal of pediatric research · 2024Article
- Hemiarthroplasty for Hip Fracture in Down Syndrome: A Retrospective Series of Five Cases.Hip & pelvis · 2024Article
- Airway Management and General Anesthesia in Pediatric Patients with Special Needs Undergoing Dental Surgery: A Retrospective Study.Reports (MDPI) · 2024Article
- Article
- Ocular Cyclopentolate: A Mini Review Concerning Its Benefits and Risks.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Approximately one in every 700 babies in the United States is born with Down syndrome, or 0.14%. Children with Down syndrome have cognitive impairment and congenital malformations necessitating frequent occurrences of general anesthesia and surgery. The thoughtful perioperative care of children with Down syndrome is relevant and acutely complex for the pediatric anesthesiologist. Behavior, sedation, hypotonia, upper airway obstruction, venous access, and bradycardia are omnipresent concerns apart from the surgical pathology. Down syndrome is also associated with autonomic nervous system dysfunction, a comorbidity that is overlooked in discussions of perioperative care and is described thus far in adults. Autonomic nervous system function or dysfunction may explain the phenotypical features of the perioperative challenges listed above. For this reason, understanding the development and measurement of autonomic nervous system function is important for the pediatric anesthesiologist. Definition and quantification of sympathetic and parasympathetic function will be reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.