ArticleCurrent topics in behavioral neurosciences2022
Pleasure, Reward Value, Prediction Error and Anhedonia.
Article in Current topics in behavioral neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The relationship between renin-angiotensin system-modulating medication and depression: a systematic review.Translational psychiatry · 2026Pooled it
- Assessing anhedonia in Chinese healthy and depressed adolescents: reliability, validity, and clinical utility of the anhedonia scale for adolescent.BMC psychiatry · 2026Article
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- Patient perspectives on the challenges, obstacles, and opportunities in discussing and managing anhedonia in major depressive disorder (MDD): a focus group study.Annals of general psychiatry · 2026Article
- Inefficient integration between effort and reward in anhedonia.Psychological medicine · 2026Article
- Metabolism and the Mind: Investigating the Link Between Glucose Control and Reinforcement Learning in Humans.Biological psychiatry global open science · 2026Article
- Anhedonic Traits Do Not Impair Performance in a 3-Arm Bandit Task.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Born to act: Deferred action and desire as active inference.Cognitive, affective & behavioral neuroscience · 2025Review
- Aberrant neural event segmentation during a continuous social narrative in trauma-exposed older adolescents and young adults.Cognitive, affective & behavioral neuroscience · 2025Article
- Pretreatment anhedonia as a predictor of exposure-based anxiety treatment outcomes.Journal of psychiatric research · 2025Article
- Anhedonia as a Core Symptom of Depression and a Construct for Biological Research.Focus (American Psychiatric Publishing) · 2025Article
- A randomized controlled trial of adjunctive iTBS targeting the dorsomedial prefrontal cortex for anhedonia in schizophrenia: rationale and protocol design.Frontiers in psychiatry · 2025Article
- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- Reward anticipation-related neural activation following cued reinforcement in adults with psychotic psychopathology and biological relatives.Psychological medicine · 2024Article
- Anhedonia influences threat avoidance and relief: A conceptual replication.Journal of mood and anxiety disorders · 2024Article
- Acute stress selectively blunts reward anticipation but not consumption: An ERP study.Neurobiology of stress · 2023Article
- Longitudinal decline in striatal dopamine transporter binding in Parkinson's disease: associations with apathy and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis.BMC psychiatry · 2023Article
- Anhedonia and Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Review
- Social Media as a Behavioral Activation Tool, Conferring Possible Protection Against Suicidal Thoughts Among Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to develop effective treatments for anhedonia we need to understand its underlying neurobiological mechanisms. Anhedonia is conceptually strongly linked to reward processing, which involves a variety of cognitive and neural operations. This chapter reviews the evidence for impairments in experiencing hedonic response (pleasure), reward valuation and reward learning based on outcomes (commonly conceptualised in terms of "reward prediction error"). Synthesising behavioural and neuroimaging findings, we examine case-control studies of patients with depression and schizophrenia, including those focusing specifically on anhedonia. Overall, there is reliable evidence that depression and schizophrenia are associated with disrupted reward processing. In contrast to the historical definition of anhedonia, there is surprisingly limited evidence for impairment in the ability to experience pleasure in depression and schizophrenia. There is some evidence that learning about reward and reward prediction error signals are impaired in depression and schizophrenia, but the literature is inconsistent. The strongest evidence is for impairments in the representation of reward value and how this is used to guide action. Future studies would benefit from focusing on impairments in reward processing specifically in anhedonic samples, including transdiagnostically, and from using designs separating different components of reward processing, formulating them in computational terms, and moving beyond cross-sectional designs to provide an assessment of causality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.