ReviewCurrent osteoporosis reports2022
Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection.
Review in Current osteoporosis reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cost-Effectiveness of Population-Level Fluoride Policies: A Systematic Review of Health and Economic Outcomes.International dental journal · 2026Pooled it
- Impact of Z-spring appliance and clear aligner therapy on oral microorganisms in children: A clinical trial.Saudi medical journal · 2025Trial
- Natural Teeth Present and Quality of Life in Older Adults from Indigenous Communities in the Peruvian Amazon: A Cross-Sectional Study.Oral health & preventive dentistry · 2026Observational
- Investigation of enamel surface changes in teeth with artificially produced white spot lesions after debonding: an in vitro study.BMC oral health · 2026Article
- Incidence and distribution of white spot lesions after clear aligner versus fixed appliance therapy : A retrospective digital photograph and intraoral scan analysis.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Article
- Accuracy and bias of high-frequency ultrasonography in measuring white spot lesion depth: an in-vitro comparison with micro-CT.Clinical oral investigations · 2026Article
- [The Oral Microbiome: Maintenance of Homeostasis, Disease Associations, and Mechanisms of Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Comparative Study on the Surface Properties of Synthetic Carbonated Hydroxyapatite and Natural Hydroxyapatite Before and After Contact with Solutions with de- and Remineralization Activity.Biomimetics (Basel, Switzerland) · 2026Article
- Influence of White Spot Lesion Severity on the Structural, Optical, and Mechanical Outcomes of Resin Infiltration: An In Vitro Study.Diagnostics (Basel, Switzerland) · 2026Article
- Dental caries beyond eradication: microbiome centered and equilibrium driven therapeutic strategies.Archives of microbiology · 2026Review
- The Use of Raman Spectroscopy in the Assessment of the Infiltration Depth of Experimental and Commercial Resin Materials in Extracted Teeth.Sensors (Basel, Switzerland) · 2026Article
- Salivary proteins, proteases, and disease pathophysiology in oral health and precision diagnostics: a narrative review.Frontiers in dental medicine · 2026Review
- Influence of low viscosity resin infiltrant on the adhesion of orthodontic attachments.Dental press journal of orthodontics · 2026Article
- Enamel Microhardness of Resin-Infiltrated White Spot Lesions After Bleaching With and Without ACP: An In Vitro Study.International journal of dentistry · 2026Article
- Automated Classification of Enamel Caries from Intraoral Images Using Deep Learning Models: A Diagnostic Study.Journal of clinical medicine · 2025Article
- Relationship of finger dermatoglyphics with ameloglyphics and their values as dental caries predictors in primary teeth.BMC oral health · 2025Article
- Review
- Effect of Fluoride Varnish on Enamel Microhardness: An in vitro Study.Clinical, cosmetic and investigational dentistry · 2025Article
- Article
- Antihypertensive Drugs and Dental Caries Risk: A Drug-Target Mendelian Randomization Analysis.International journal of genomics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewCompare noninfectious (part I) to infectious (part II) demineralization of bones and teeth. Evaluate similarities and differences in the expression of hard tissue degradation for the two most common chronic demineralization diseases: osteoporosis and dental caries. RECENT
findingsThe physiology of demineralization is similar for the sterile skeleton compared to the septic dentition. Superimposing the pathologic variable of infection reveals a unique pathophysiology for dental caries. Mineralized tissues are compromised by microdamage, demineralization, and infection. Osseous tissues remodel (turnover) to maintain structural integrity, but the heavily loaded dentition does not turnover so it is ultimately at risk of collapse. A carious tooth is a potential vector for periapical infection that may be life-threatening. Insipient caries is initiated as a subsurface decalcification in enamel that is not detectable until a depth of ~400μm when it becomes visible as a white spot. Reliable detection and remineralization of invisible caries would advance cost-effective wellness worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.