ArticlePsychoradiology2021
Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample.
Article in Psychoradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- Early deviations from normative brain morphology and cortical microstructure in schizophrenia spectrum disorders.Translational psychiatry · 2026Article
- Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.Brain imaging and behavior · 2025Article
- Machine learning-based prediction of antipsychotic efficacy from brain gray matter structure in drug-naive first-episode schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis.Schizophrenia bulletin · 2024Article
- Identify Potential Causal Relationships Between Cortical Thickness, Mismatch Negativity, Neurocognition, and Psychosocial Functioning in Drug-Naïve First-Episode Psychosis Patients.Schizophrenia bulletin · 2024Article
- Sleep Traits Causally Affect the Brain Cortical Structure: A Mendelian Randomization Study.Biomedicines · 2023Article
- Cortical and subcortical brain morphometry abnormalities in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.Psychiatry research. Neuroimaging · 2023Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundAbnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent.
objectiveTo define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies.
methodsThe meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction.
resultsThe meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis.
conclusionThis study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.
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