Evidence map›Paper›PMID 35155983›Full record

ArticleCurrent developments in nutrition2022

Longitudinal Assessment of Prenatal, Perinatal, and Early-Life Aflatoxin B

Joshua W Smith, Andrew J Matchado, Lee S-F Wu, Charles D Arnold, Sean M Burke, Kenneth M Maleta, Per Ashorn, Christine P Stewart, Saijuddin Shaikh, Hasmot Ali and 6 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00860470 phase3completednot on this map

Antenatal Multiple Micronutrient Supplementation to Improve Infant Survival and Health in Bangladesh

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2008 to 2012Enrolled44,567ConditionsInfant Mortality, Preterm Birth, Low Birth Weight, Neonatal MortalityArmsIron (27 mg) - folic acid (600 ug), Multiple micronutrient
NCT01239693 phase3active not recruitingnot on this map

A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)

TypeinterventionalSponsorTampere UniversityRan2011 to 2027Enrolled1,391ConditionsInfant Malnutrition, Malnutrition in PregnancyArmsIFA, MMN, LNS
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Joshua W SmithDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-8636-8097
Andrew J MatchadoDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, Davis, CA, USA.
Lee S-F WuCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Charles D ArnoldDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, Davis, CA, USA.
Sean M BurkeDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Kenneth M MaletaSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Per AshornTampere University, Faculty of Medicine and Health Technology, Center for Child, Adolescent and Maternal Health Research and Tampere University Hospital, Department of Pediatrics, Tampere, Finland.
Christine P StewartDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0003-4575-8571
Saijuddin ShaikhCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-5095-1478
Hasmot AliCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-0044-1992
Alain B LabriqueCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Keith P WestCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Parul ChristianCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Kathryn G DeweyDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, Davis, CA, USA.
John D GroopmanDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Kerry J SchulzeCenter for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of California, Davis · USUniversity of Malawi · MWTampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn utero or early-life exposure to aflatoxin, which contaminates staple crops in disadvantaged settings, may compromise pregnancy and infant outcomes, but investigations into the extent, persistence, and determinants of aflatoxin exposure at these life stages have lacked longitudinal data collection and broad geographic representation.

objectivesAflatoxin exposure and selected determinants thereof were characterized in mother-child dyads with serial plasma/serum samples in prenatal, perinatal, and early life in Malawi and Bangladesh.

methodsCirculating aflatoxin B

resultsMaternal AFB

conclusionsAmong pregnant women, aflatoxin exposure was persistently high in Malawi, while lower and seasonal in Bangladesh. Infants were partially protected from exposure in utero and with exclusive breastfeeding, but exposures reached adult levels by 18-24 mo of age. The Bangladesh and Malawi trials are registered at clinicaltrials.gov as NCT00860470 and NCT01239693.

Indexed as

aflatoxinbreastfeedingcord blooddietinfancymass spectrometrypregnancyseasonalitytoxicology

Identifiers

PMID35155983
PMCPMC8829025
OpenAlexW4205173068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.