Evidence map›Paper›PMID 35155918›Full record

ArticleACS omega2022

Breath Analysis for the In Vivo Detection of Diabetic Ketoacidosis.

Mizaj Shabil Sha, Muni Raj Maurya, Sadiyah Shafath, John-John Cabibihan, Abdulaziz Al-Ali, Rayaz A Malik, Kishor Kumar Sadasivuni

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mizaj Shabil ShaCenter for Advanced Materials, Qatar University, P.O. Box 2713, Doha 2713, Qatar.
Muni Raj MauryaCenter for Advanced Materials, Qatar University, P.O. Box 2713, Doha 2713, Qatar.
Sadiyah ShafathCenter for Advanced Materials, Qatar University, P.O. Box 2713, Doha 2713, Qatar.
John-John CabibihanDepartment of Mechanical and Industrial Engineering, Qatar University, P.O. Box 2713, Doha 2713, Qatar.
Abdulaziz Al-AliDepartment of Computer Science and Engineering, Qatar University, P.O. Box 2713, Doha 2713, Qatar.
Rayaz A MalikWeill Cornell Medicine-Qatar, Qatar Foundation-Education City, P.O. Box 24144, Doha 2713, Qatar.
Kishor Kumar SadasivuniCenter for Advanced Materials, Qatar University, P.O. Box 2713, Doha 2713, Qatar.ORCID https://orcid.org/0000-0003-2730-6483
Qatar University · QAWeill Cornell Medical College in Qatar · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human breath analysis of volatile organic compounds has gained significant attention recently because of its rapid and noninvasive potential to detect various metabolic diseases. The detection of ketones in the breath and blood is key to diagnosing and managing diabetic ketoacidosis (DKA) in patients with type 1 diabetes. It may also be of increasing importance to detect euglycemic ketoacidosis in patients with type 1 or type 2 diabetes or heart failure, treated with sodium-glucose transporter-2 inhibitors (SGLT2-i). The present research evaluates the efficiency of colorimetry for detecting acetone and ethanol in exhaled human breath with the response time, pH effect, temperature effect, concentration effect, and selectivity of dyes. Using the proposed multidye system, we obtained a detection limit of 0.0217 ppm for acetone and 0.029 ppm for ethanol in the detection range of 0.05-50 ppm. A smartphone-assisted unit consisting of a portable colorimetric device was used to detect relative red/green/blue values within 60 s of the interface for practical and real-time application. The developed method could be used for rapid, low-cost detection of ketones in patients with type 1 diabetes and DKA and patients with type 1 or type 2 diabetes or heart failure treated with SGLT2-I and euglycemic ketoacidosis.

Identifiers

PMID35155918
PMCPMC8830064
OpenAlexW4206936376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.