ReviewLaryngoscope investigative otolaryngology2022
Contemporary management of paragangliomas of the head and neck.
Review in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025.Endocrine journal · 2026Guideline
- Tumor progression in tympanojugular paragangliomas: the role of radiotherapy and wait and scan.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- Metastatic Carotid Body Paraganglioma Following Three Decades of Indolent Growth: A Case Report.Cureus · 2026Article
- Synchronous Bilateral Carotid Body and Bilateral Vagal Paragangliomas: A Case Report and Literature Review.Journal of clinical medicine · 2026Article
- Rates of Hereditary Paraganglioma Syndromes and Secretory Head and Neck Paragangliomas: A Single-Institution Experience.Journal of neurological surgery. Part B, Skull base · 2026Article
- Carotid body tumors: A 10-year observation study of clinical presentation and surgical outcomes.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Malignant paraganglioma of the vagus nerve: diagnostic and therapeutic strategies-a case report.Journal of medical case reports · 2025Article
- Chemoradiotherapy for recurrent CBTs case report.Discover oncology · 2025Article
- Pros and cons of surgical versus conservative management for head and neck paraganglioma: a real-world data analysis.Endocrine · 2025Article
- Pheochromocytomas and Paragangliomas-Current Management.Cancers · 2025Review
- Imaging of the skull base and orbital tumors.Japanese journal of radiology · 2025Review
- Management of bilateral head and neck paragangliomas at a single-institution across four decades.Head & neck · 2025Article
- Microsurgical resection of a giant exclusively dopamine- secreting jugular foramen paraganglioma: A case report.Surgical neurology international · 2025Article
- Multidisciplinary Management of Lateral Skull Base Paragangliomas: A 20-Year Experience.Journal of neurological surgery. Part B, Skull base · 2024Article
- Management and follow-up strategies for patients with head and neck paraganglioma.European journal of endocrinology · 2024Article
- Clinical Characteristics and Outcomes of Tympanomastoid Paragangliomas: A Report from Slovenia.Cancers · 2024Article
- [Advance in HIF expression and immune microenvironment in pseudohypoxic HNPGL].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Review
- [Endothelial cells and fibroblasts mediate the microenvironmental regulatory network of carotid body paraganglioma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Single-cell RNA-Seq reveals the heterogeneity of fibroblasts within the tympanojugular paraganglioma microenvironment.Heliyon · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors typically arising from nonsecretory head and neck parasympathetic ganglia. Historically thought of as aggressive tumors that warranted equally aggressive surgical intervention, evidence has emerged demonstrating that the vast majority of HNPGLs are slow growing and indolent. It is also now recognized that a large proportion of HNPGLs are hereditary with succinate dehydrogenase gene mutations typically implicated. These recent advances have led to significant changes in the way in which clinicians investigate and treat HNPGLs with most now opting for more conservative treatment strategies. However, a proportion of patients present with more aggressive disease and still require nonconservative treatment strategies. Recent studies have sought to determine in which groups of patients the morbidity associated with treatment is justified. We summarize the recent advances in the understanding and management of these tumors and we provide our recommendations regarding the management of HNPGLs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.