ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022
Endurance and gait speed relationships with mild cognitive impairment and dementia.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Machine Learning Approaches for Dementia Detection Through Speech and Gait Analysis: A Systematic Literature Review.Journal of Alzheimer's disease : JAD · 2024Pooled it
- Factors associated with the risk of falls and their relationship with cognitive function in older adults with cognitive impairment: a cross-sectional study.GeroScience · 2026Article
- Association of Cholinergic Stimulation with Improved Functional Performance and Neurotrophic Markers in Mild Cognitive Impairment.Molecular neurobiology · 2026Article
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- Predicting the onset of dementia with longitudinal performance-based measures of physical function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Comparison of Wearable and Depth-Sensing Technologies with Electronic Walkway for Comprehensive Gait Analysis.Sensors (Basel, Switzerland) · 2025Article
- Accelerometer Measurements: A Learning Tool to Help Older Adults Understand the Importance of Soft-Landing Techniques in a Community Walking Class.Sensors (Basel, Switzerland) · 2025Article
- Physical fitness and incident mild cognitive impairment: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- The Longitudinal Relationship Between Physical Functions and Cognitive Functions Among Middle-Aged and Older Adults in Primary Care.International journal of environmental research and public health · 2025Article
- Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis.Frontiers in aging neuroscience · 2025Article
- Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers.Frontiers in aging · 2025Article
- Motor and cognitive function after unipolar depressive episodes: a 6 years longitudinal observational study.Frontiers in psychology · 2025Article
- Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.Neuro-degenerative diseases · 2024Article
- Curve Walking Reveals More Gait Impairments in Older Adults with Mild Cognitive Impairment than Straight Walking: A Kinect Camera-Based Study.Journal of Alzheimer's disease reports · 2024Article
- Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank.BMC medicine · 2022Article
- Gait Speed and Sleep Duration Is Associated with Increased Risk of MCI in Older Community-Dwelling Adults.International journal of environmental research and public health · 2022Article
- Endurance and gait speed relationships with mild cognitive impairment and dementia.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease.Frontiers in aging neuroscience · 2022Article
- Widespread gray and white matter microstructural alterations in dual cognitive-motor deficit.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Low intrinsic capacity is associated with a blunted exercise-induced cognitive enhancement in physically active middle-aged and older adults.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
introductionSlower mobility is associated with mild cognitive impairment (MCI) and dementia. We examined the interaction of endurance with gait speed on prevalent MCI and dementia.
methodsCross-sectional multinomial regression in the ARIC cohort (n = 2844 participants; 71 to 94 years; 44% men; 18% Black persons) with cognitive status (normal/MCI/dementia), 4 m gait speed, and endurance (2 minute walk [2MW]).
resultsFaster gait speed (up to but not above 1 m/s) and better 2MW were separately associated with lower dementia risk. Good performance in both (2MW = 200 m, gait speed = 1.2 m/s) was associated with 99% lower dementia (Relative Prevalence Ratio [RPR] = 0.01 [95% CI: 0.0 to 0.06]) and 73% lower MCI, RPR = 0.27 (0.15 to 0.48) compared to poor performance in both (2MW = 100 m, gait speed = 0.8 m/s). Models incorporating a gait speed-by-2MW interaction term outperformed gait speed-only models ( DISCUSSION: Gait speed relationships with dementia diminish at faster gait speeds. Combining endurance with gait speed may yield more sensitive markers of MCI and dementia than gait speed alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.