Evidence map›Paper›PMID 35155545›Full record

ArticleFrontiers in surgery2021

Adding Consolidation Capecitabine to Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Propensity-Matched Comparative Study.

Yifang Fang, Chengmin Sheng, Feng Ding, Weijie Zhao, Guoxian Guan, Xing Liu

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05496491 (Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05496491 narecruitingnot on this mapstarted 2022, after this paper: background citation

Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer: A Randomized Controlled Trial

TypeinterventionalSponsorLarissa University HospitalRan2022 to 2029Enrolled84ConditionsRectal NeoplasmsArmsNeoadjuvant Chemoradiotherapy, Adjuvant Chemotherapy, Consolidation Chemotherapy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yifang FangDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Chengmin ShengFuzhou Medical College of Nanchang University, Fuzhou, China.
Feng DingDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Weijie ZhaoDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Guoxian GuanDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Xing LiuDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CNFuzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine whether adding consolidation capecitabine chemotherapy without lengthening the waiting period influences pathological complete response (pCR) and short-term outcome of locally advanced rectal cancer (LARC) receiving neoadjuvant chemoradiotherapy (NCRT).

methodTotally, 545 LARC who received NCRT and radical resection between 2010 and 2018 were enrolled. Short-term outcome and pCR rate were compared between patients with and without additional consolidation capecitabine. Logistic analysis was performed to identify predictors of pCR.

resultsAfter propensity score matching, 229 patients were matched in both NCRT and NCRT-Cape groups. Postoperative morbidity was comparable between groups except for operation time, which is lower in the NCRT group (213.2 ± 67.4 vs. 227.9 ± 70.5,

conclusionAdding consolidation capecitabine chemotherapy without lengthening CRT-to-surgery interval in LARC patients after NCRT does not seem to impact pCR or short-term outcome. A predictive nomogram for pCR was successful, and it could support treatment decision-making.

Indexed as

capecitabineneoadjuvant chemoradiotherapyprognosispropensity score matched analysisrectal neoplasm

Identifiers

PMID35155545
PMCPMC8830484
OpenAlexW4210523032

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.