Evidence map›Paper›PMID 35155495›Full record

ArticleFrontiers in medicine2022

A Patients' Perspective Towards the Injection Devices for Humira® and Imraldi® in a Nationwide Switching Program.

Kristin Karlsdottir, Anna I Gunnarsdottir, Gerdur Grondal, Thorvardur J Love, Elinborg Stefansdottir, Loa G Davidsdottir, Ragna H Thorleifsdottir, Bjorn Gudbjornsson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Patients' Perceptions of Biosimilars: A Systematic Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Pooled it
  2. Article
  3. Switching from Adalimumab Reference Product to and Among Adalimumab Biosimilars Outside the USA: Insights for US Clinicians.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  4. Observational
  5. Article
  6. Navigating adalimumab biosimilars: an expert opinion.Journal of comparative effectiveness research · 2023
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kristin KarlsdottirHospital Pharmacy, Landspitali University Hospital, Reykjavik, Iceland.
Anna I GunnarsdottirHospital Pharmacy, Landspitali University Hospital, Reykjavik, Iceland.
Gerdur GrondalCentre for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland.
Thorvardur J LoveSchool of Health Sciences, University of Iceland, Reykjavik, Iceland.
Elinborg StefansdottirDepartment of Rheumatology, Landspitali University Hospital, Reykjavik, Iceland.
Loa G DavidsdottirDepartment of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland.
Ragna H ThorleifsdottirSchool of Health Sciences, University of Iceland, Reykjavik, Iceland.
Bjorn GudbjornssonSchool of Health Sciences, University of Iceland, Reykjavik, Iceland.
Reykjavík University · ISUniversity of Iceland · ISInnovation Center Iceland · ISNational University Hospital of Iceland · IS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDue to a tender process in Iceland, all patients on Humira® were switched nationwide to its biosimilar Imraldi® in March 2019. The study aimed to explore the patient's perspective of the Humira® and Imraldi® injection devices.

methodsA standard telephone interview was carried out among patients with inflammatory arthritis, inflammatory bowel disease and psoriasis, who underwent this nationwide switching program a few months earlier.

resultsThe response rate was 84.5% (

conclusionPatients with inflammatory disorders who have been treated regularly with adalimumab preferred the Humira® injection device over the Imraldi® device, according to our results. After all, these injection devices' structure and content are not the same, although both contain the same active ingredient, i.e. adalimumab. Our results highlight the importance of thorough information, not only with an information letter but also with the possibilities for individualized introduction in planning switching to biosimilars.

Indexed as

adalimumabHumiraImraldiinjection devicesmedicine administration at home

Identifiers

PMID35155495
PMCPMC8829031
OpenAlexW4210295335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.