ArticleFrontiers in bioengineering and biotechnology2021
The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis.
Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- The influence of stenosis severity and geometric orientation on atherosclerotic progression: A fluid-structure interaction study in the carotid artery.Physical and engineering sciences in medicine · 2026Article
- Hemodynamic Effects of Aortic Stenosis on Coronary Flow Dynamics.Annals of biomedical engineering · 2026Article
- Haemodynamic and biomechanical biomarker analysis of carotid fibromuscular dysplasia via fluid-structure interaction.Biomechanics and modeling in mechanobiology · 2026Article
- Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors.Translational stroke research · 2026Observational
- Article
- Risk stratification in intermediate asymptomatic carotid artery disease: a multi-modal approach combining local flow dynamics and systemic clinical profiles.Frontiers in surgery · 2026Article
- Hemodynamic Impact of the Aberrant Subclavian Artery: A CFD Investigation.Journal of personalized medicine · 2025Article
- From Heart to Abdominal Aorta: Integrating Multi-Modal Cardiac Imaging Derived Haemodynamic Biomarkers for Abdominal Aortic Aneurysm Risk Stratification, Surveillance, Pre-Operative Assessment and Therapeutic Decision-Making.Diagnostics (Basel, Switzerland) · 2025Review
- A systematic evaluation of the impact of contralateral stenosis on ipsilateral internal carotid artery hemodynamics using computational fluid dynamics.Quantitative imaging in medicine and surgery · 2025Article
- Temporal evolution of hemodynamics in murine arteriovenous fistula: A micro-CT based CFD study.PLoS computational biology · 2025Article
- Hemodynamics in carotid artery stenosis.International angiology : a journal of the International Union of Angiology · 2025Review
- Plaque biomarkers from high-frame rate vector flow imaging and shear wave elastography in mild carotid stenosis.Ultrasonography (Seoul, Korea) · 2025Article
- Review
- High Wall Shear Stress Is Related to Complicated American Heart Association Lesion Type VI Plaques in Mild-to-Moderate ICA Stenosis: A 3D Cardiovascular MRI Study.AJNR. American journal of neuroradiology · 2025Article
- To patch or not to patch: is that the real question? The role of hemodynamics in carotid endarterectomy. Illustrative cases.Journal of neurosurgery. Case lessons · 2025Article
- Anatomical location-related hemodynamic variations are associated with atherosclerosis in the middle cerebral artery: a preliminary cross-sectional 4D flow and 3D vessel wall MRI study.Quantitative imaging in medicine and surgery · 2025Article
- Hemodynamic effects of stenosis with varying severity in different segments of the carotid artery using computational fluid dynamics.Scientific reports · 2025Article
- Enhancing cardiac assessments: accurate and efficient prediction of quantitative fractional flow reserve.Frontiers in bioengineering and biotechnology · 2025Article
- The effects of carotid plaque classification and bifurcation angle on plaque: a computational fluid dynamics simulation.Frontiers in physiology · 2025Article
- Emerging role of IRE1α in vascular diseases.Journal of cell communication and signaling · 2024Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two WSS metrics, time-averaged WSS (TAWSS) and the oscillatory shear index (OSI), and the local histologically determined plaque composition in a set of advanced human carotid plaques. Our dataset of 11 carotid endarterectomy samples yielded 87 histological cross-sections, which yielded 511 radial bins for analysis. Both TAWSS and OSI values were subdivided into patient-specific low, mid, and high tertiles. This cross-sectional study shows that necrotic core (NC) size and macrophage area are significantly larger in areas exposed to high TAWSS or low OSI. Local TAWSS and OSI tertile values were generally inversely related, as described in the literature, but other combinations were also found. Investigating the relation between plaque vulnerability features and different combinations of TAWSS and OSI tertile values revealed a significantly larger cap thickness in areas exposed to both low TAWSS and low OSI. In conclusion, our study confirmed previous findings, correlating high TAWSS to larger macrophage areas and necrotic core sizes. In addition, our study demonstrated new relations, correlating low OSI to larger macrophage areas, and a combination of low TAWSS and low OSI to larger cap thickness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.