ArticleFrontiers in public health2021
Mediating Effect of Body Mass Index and Dyslipidemia on the Relation of Uric Acid and Type 2 Diabetes: Results From China Health and Retirement Longitudinal Study.
Article in Frontiers in public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Effects of exercise intervention on body morphology in obese college students: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Article
- Reference interval of serum uric acid among healthy children and adolescents in Nanjing, China, and influencing factors.Annals of medicine · 2025Article
- Sex-specific associations between serum uric acid levels and risk of hypertension for different diagnostic reference values of high blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Synergistic effect of schizandrin A and DNase I knockdown on high glucose induced beta cell apoptosis by decreasing intracellular calcium concentration.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Fatty liver mediates the association of hyperuricemia with prediabetes and diabetes: a weighting-based mediation analysis.Frontiers in endocrinology · 2023Article
- Spatiotemporal Analysis and Risk Assessment Model Research of Diabetes among People over 45 Years Old in China.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study assessed temporal relationships of serum uric acid (SUA) with blood glucose and determine the mediating effects of body mass index (BMI) and dyslipidemia on the relation of SUA and risk of type 2 diabetes.
methodsParticipants aged ≥ 45 years were participated in 2011 and followed up until 2015. Cox proportional hazards regression with a robust variance estimator was performed to explore the association of SUA with the risk of diabetes, and crosslagged path analysis was introduced to examine the temporal relationships between SUA and blood glucose. A mediation analysis was finally used to identify the mediating effect of BMI and dyslipidemia on the relation of SUA and the future risk of diabetes.
resultsA total of 9,020 participants were included with an average age of 58.59 years at baseline in 2011, and 53.6% of them were women. Linear dose-response relationship was identified by restricted spline cubic analysis between baseline SUA and follow-up blood glucose (the non-linear trend for fasting plasma glucose (FPG): β
conclusionsThese findings provide strong evidence that hyperuricemia preceded diabetes, and the effect of baseline SUA on follow-up type 2 diabetes was more pronounced among middle-aged and elderly Chinese women, especially in postmenopausal women, and this effect is partly mediated by BMI and dyslipidemia at baseline.
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